Ubiquitin Carboxyl Hydrolase L1 Significance for Human Diseases
Ubiquitin Carboxyl Hydrolase L1 Significance for Human Diseases
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DOI：
10.2174/0929866521666140403125959
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发表时间：
2014-01-01
影响因子：
1.6
通讯作者：
Tran Linh Thuoc
中科院分区：
文献类型：
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作者：
Dang Ngoc Anh Suong;Dang Thi Phuong Thao;Tran Linh Thuoc
泛素羧基水解酶 L1 (UCH-L1) 是一种丰富的多功能神经元蛋白。它在维持泛素蛋白酶体系统 (UPS) 方面发挥着重要作用，对于识别和降解生物体中功能失调的蛋白质至关重要。近几十年来，UCH-L1 与许多疾病的发病机制有关，包括神经退行性疾病、癌症和糖尿病。然而，UCH-L1参与的机制尚未详细揭示。由于UCH-L1对细胞代谢贡献多种不同的功能，其作用和调控可能比之前想象的更加复杂，已成为许多实验室的研究目标。在这篇综述中，我们总结了与 UCH-L1 在几种人类疾病中的作用相关的最新发现。
Ubiquitin carboxyl hydrolase L1 (UCH-L1) is an abundant multifunctional neuron protein. It plays an important role in maintaining the ubiquitin proteasome system ( UPS), vital for recognizing and degrading dysfunctional proteins in organisms. In recent decades, UCH-L1 has been implicated in the pathogenesis of many diseases, including neurodegenerative disorders, cancer and diabetes. However, the mechanisms of UCH-L1 involvement have yet to be revealed in detail. Since UCH-L1 contributes many different functions to cell metabolism, its role and regulation might be more complex than previously thought and it has become a research target in many laboratories. In this review, we summarize recent findings related to the actions of UCH-L1 in several human diseases.