Two plus two does not equal three: statistical tests for multiple genome comparison.
Two plus two does not equal three: statistical tests for multiple genome comparison.
复制标题
二加二不等于三：多基因组比较的统计检验。
DOI：
10.1142/s0219720008003242
复制
发表时间：
2008
影响因子：
1
通讯作者：
Durand,Dannie
中科院分区：
文献类型：
--
作者：
Raghupathy,Narayanan;Hoberman,Rose;Durand,Dannie
Gene clusters that span three or more chromosomal regions are of increasing importance, yet statistical tests to validate such clusters are in their infancy. Current approaches either conduct several pairwise comparisons or consider only the number of genes that occur in all of the regions. In this paper, we provide statistical tests for clusters spanning exactly three regions based on genome models of typical comparative genomics problems, including analysis of conserved linkage within multiple species and identification of large-scale duplications. Our tests are the first to combine evidence from genes shared among all three regions and genes shared between pairs of regions. We show that our tests of clusters spanning three regions are more sensitive than existing approaches, and can thus be used to identify more diverged homologous regions.
