Comparison of pain and dyspnea perceptual responses in healthy subjects
Comparison of pain and dyspnea perceptual responses in healthy subjects
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DOI：
10.1016/j.pain.2009.11.024
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发表时间：
2010-03-01
期刊：
影响因子：
7.4
通讯作者：
Ishikawa, Teruhiko
中科院分区：
文献类型：
--
作者：
Nishino, Takashi;Yashiro, Eiko;Ishikawa, Teruhiko
呼吸困难和疼痛有许多相似之处。最近的脑成像实验表明，类似的皮层区域被呼吸困难和疼痛的感知激活。我们测试了一个人的疼痛敏感性可能平行的个人的呼吸困难敏感性的假设。在52名年轻健康受试者中进行了研究。每例受试者均发生了实验诱导的疼痛和呼吸困难。通过冷加压试验诱导疼痛，通过屏气诱导呼吸困难，同时使用视觉疼痛量表（VAS）评估疼痛和呼吸困难的不愉快体验。测定从冷刺激和屏气开始至出现不适感的时间（分别为痛阈时间和无呼吸感时间）和至耐受极限的时间（分别为疼痛耐受时间和总屏气时间）。在冷痛刺激的反应中，观察到行为二分法（疼痛耐受和疼痛敏感）。PS（疼痛敏感）组的无呼吸感觉时间显著短于PT（疼痛耐受）组（16.9 +/- 3.8 vs. 19.6 +/- 5.3 s：P < 0.05），而PT组和PS组之间的总屏气时间无显著差异。PT组和PS组的痛阈时间与无呼吸感觉时间之间均存在显著相关性。然而，在两组中均未观察到疼痛与呼吸困难耐受性之间的显著相关性。总之，个体的疼痛阈值与个体的呼吸困难阈值相关，但个体的疼痛耐受性与个体的呼吸困难耐受性并不一致。(c)2009年国际疼痛研究协会。由Elsevier B出版。V.保留所有权利。
Dyspnea and pain have a number of similarities. Recent brain imaging experiments showed that similar cortical regions are activated by the perceptions of dyspnea and pain. We tested the hypothesis that an individual's pain sensitivity might parallel the individual's dyspnea sensitivity. Studies were carried out in 52 young healthy subjects. Each subject experienced experimentally induced pain and dyspnea. Pain was induced by a cold-pressor test and dyspnea was induced by breathholding while the unpleasant experience of pain and dyspnea was assessed by using a Visual Analogue Scale (VAS). The times from the start of cold stimulation and breathholding to the onset of uncomfortable sensation (pain threshold time and the period of no respiratory sensation, respectively) and to the limit of tolerance (pain endurance time and total breathholding time, respectively) were also measured. In response to cold pain stimulation, a behavioral dichotomy (pain-tolerant and pain-sensitive) was observed. The period of no respiratory sensation was significantly shorter in the PS (pain-sensitive) group than in the PT (pain-tolerant) group (16.9 +/- 3.8 vs. 19.6 +/- 5.3 s: P < 0.05), whereas no significant difference in the total breathholding time was found between the PT and PS groups. A significant correlation was observed between the pain threshold time and the period of no respiratory sensation in both the PT and PS groups. However, no significant association was observed between pain and dyspnea tolerance in both groups. In conclusion, an individual's pain threshold is correlated to the individual's dyspnea threshold, but the individual's pain tolerance is not consistently correlated to the individual's dyspnea tolerance. (c) 2009 International Association for the Study of Pain. Published by Elsevier B. V. All rights reserved.