Changes in concentrations of free propofol by modification of the solution
Changes in concentrations of free propofol by modification of the solution
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DOI：
10.1213/01.ane.0000154191.86608.ac
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发表时间：
2005-08-01
影响因子：
5.7
通讯作者：
Namiki, A
中科院分区：
文献类型：
--
作者：
Yamakage, M;Iwasaki, S;Namiki, A
由于游离丙泊酚被认为是负责注射疼痛，我们研究了游离丙泊酚浓度的变化，通过修改两种丙泊酚产品中的中链和长链甘油三酯（MCT/LCT）乳剂和LCT乳剂。本研究中使用的技术是1）混合2%利多卡因（10：1），2）在醋酸林格氏溶液中混合5%葡萄糖以降低pH值（10：1），3）将温度改变为4 ℃、20 ℃和36 ℃。将丙泊酚制剂透析24 h，并使用高效液相色谱法分析受体介质。丙泊酚MCT/LCT组游离丙泊酚浓度比丙泊酚LCT组低30%。无论是混合利多卡因还是冷却都不会降低两种产品中游离丙泊酚的浓度，但pH值降低和温度升高会降低浓度。由于混合利多卡因可诱导丙泊酚乳剂的不稳定性，并且加热可快速诱导微生物生长，因此建议在丙泊酚给药前注射利多卡因以减轻注射疼痛。在本研究的任何情况下，丙泊酚MCT/LCT中的游离丙泊酚浓度均显著低于丙泊酚LCT中的游离丙泊酚浓度（约30%-45%）。
Because free propofol is thought to be responsible for pain on injection, we investigated the changes in concentrations of free propofol by modifying two kinds of propofol products in a medium- and long-chain triglyceride (MCT/LCT) emulsion and in an LCT emulsion. The techniques used in this study were 1) mixing 2% lidocaine (10:1), 2) mixing 5% dextrose in acetated Ringer's solution to reduce pH (10:1), and 3) changing the temperature to 4 degrees, 20 degrees, and 36 degrees C. The propofol preparations were dialyzed for 24 h, and the receptor medium was analyzed using high-performance liquid chromatography. The concentration of free propofol in propofol MCT/LCT was significantly smaller by 30% than that in propofol LCT. Neither mixing lidocaine nor cooling reduced the concentrations of free propofol in both products, but the concentrations were reduced by a decrease in pH and by an increase in temperature. Because mixing lidocaine can induce instability in an emulsion of propofol and warming can rapidly induce microbial growth, injection of lidocaine before propofol administration is recommended to reduce the pain on injection. The concentrations of free propofol in propofol MCT/LCT were significantly smaller (by approximately 30%-45%) than those in propofol LCT during any situation in this study.