Unsuspected colchicine overdose in a female patient presenting as an acute abdomen
Unsuspected colchicine overdose in a female patient presenting as an acute abdomen
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DOI：
10.1177/0310057x0703500322
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发表时间：
2007-06-01
影响因子：
1.5
通讯作者：
MacQuillan, G. C.
中科院分区：
文献类型：
--
作者：
Blackham, R. E.;Little, M.;MacQuillan, G. C.
我们报告一例多系统器官衰竭的情况下，未经怀疑秋水仙碱过量的结果，在病人已知痛风和神经性贪食症。在确定病原体之前，患者最初表现为轻微的胃肠道症状，并迅速发展为暴发性肝功能衰竭和多器官功能障碍。患者在积极的重症监护支持和持续的药物治疗下幸存下来。医生应该意识到基于摄入剂量的风险评估，秋水仙碱毒性剂量的临床表现可能是非特异性的，有很高的严重发病率或死亡的可能性，尽管多器官衰竭需要积极的支持，但仍可能存活。
We report a case of multi-system organ failure as a result of unsuspected colchicine overdose in a patient with known gout and bulimia nervosa. The patient had initially presented with mild gastrointestinal symptoms with rapid progression to fulminant hepatic failure and multiple organ dysfunction before the causative agent was identified. The patient survived with aggressive intensive care support and ongoing medical treatment. Physicians should be aware of the risk assessment based on the ingested dose, that the clinical presentation of colchicine in toxic doses may be nonspecific with high potential for severe morbidity or death and that survival may occur despite multiple organ failure requiring aggressive support.