A polyimide pressure-contact multielectrode array for implantation along a submillimeter neural process in small animals.
A polyimide pressure-contact multielectrode array for implantation along a submillimeter neural process in small animals.
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一种聚酰亚胺压力接触多电极阵列，用于沿着小动物的亚毫米神经过程植入。
DOI：
10.1109/tbme.2008.919122
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Hoy,RonaldR
中科院分区：
文献类型：
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作者：
Lott3rd,GusK;Hoy,RonaldR
我们描述了一种用于记录直径从20-200微米的神经束的微电极系统。一种新颖的聚酰亚胺结构允许平面微制造器件将自由神经过程限制在几个记录位置上。这种聚酰亚胺阵列包含多个锯齿形通孔，通过这些通孔可以编织一个小的神经突起，同时在活体制剂中保持功能完整。我们的电极结构具有神经袖带的优点(聚合物中均匀分布的电极)和神经钩的功能(能够连接到亚毫米级的过程)。该设备记录了红色沼泽小龙虾克氏原虾的细胞外动作电位。在这个模型生物体的周围神经系统中，沿着受限制的神经的几个位置监测了动作电位的传播。详细讨论了微电极阵列绝对传导速度测量的时间精度和误差来源。
We describe a microelectrode system for recordings from nerve bundles with diameters ranging from 20-200 mum. A novel polyimide structure allows for a planar microfabricated device to constrain a free neural process against several recording sites. This polyimide array contains multiple zigzag vias through which a small nerve process may be woven while remaining functionally intact in a live preparation. Our electrode construct features the benefits of nerve cuffs (evenly spaced electrodes in a polymer) and the functionality of a nerve hook (ability to connect to submillimeter processes). The device records extracellular action potentials in the red-swamp crayfish, Procambarus clarkii. Action potential propagation is monitored at several sites along a constrained nerve in this model organism's peripheral nervous system. Details of temporal accuracy and error sources in absolute conduction velocity measurements from microelectrode arrays are discussed.