Combined chemotherapy and radiation therapy for central nervous system germ cell tumors: preliminary results of a Phase II study of the Japanese Pediatric Brain Tumor Study Group.
Combined chemotherapy and radiation therapy for central nervous system germ cell tumors: preliminary results of a Phase II study of the Japanese Pediatric Brain Tumor Study Group.
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联合化疗和放射治疗中枢神经系统生殖细胞肿瘤：日本小儿脑肿瘤研究组 II 期研究的初步结果。
作者：
M. Matsutani;Y. Ushio;H. Abe;J. Yamashita;S. Shibui;T. Fujimaki;K. Takakura;K. Nomura;R. Tanaka;M. Fukui;T. Yoshimoto;T. Hayakawa;T. Nagashima;K. Kurisu;T. Kayama
作者进行了一项多机构 II 期研究，旨在为脑部原发性生殖细胞肿瘤患者建立术后联合化疗和放射治疗方案。经过肿瘤减瘤手术和组织学验证后，将患者分为三个治疗组：预后良好组、预后中等组和预后不良组。患者在接受放射治疗前接受了两种化疗（三个疗程）：卡铂-依托泊苷组合（[CARB-VP]：第1天卡铂450 mg/m(2)，第1-3天依托泊苷150 mg/m(2)）或异环磷酰胺-顺铂-依托泊苷组合（[ICE]：异环磷酰胺900 mg/m(2)，顺铂20 mg/m(2)，依托泊苷 60 mg/m(2)（第 1-5 天）。预后良好组的患者（生殖细胞瘤患者）接受 CARB-VP 治疗，然后进行局部放射治疗（24 Gy）。中期预后组患者接受CARB-VP，随后接受局部放射治疗（50 Gy）；他们接受了五次额外的化疗。预后不良组患者接受ICE治疗后进行全颅脊髓放射治疗；他们还接受了五次额外的化疗。八十二名患者接受了评估。 56例生殖细胞瘤患者治疗后完全缓解率达93%。中间预后组21名患者的缓解率为76%，中位随访2.6年未发现复发。在5名预后不良的患者中，3名患者在化疗或放疗期间病情进展，并在6个月内死亡。幸存的患者没有出现严重并发症。作者发现他们的治疗方案目前对于生殖细胞瘤患者和预后中等的患者有效。
The authors conducted a multiinstitutional phase II study to establish a postsurgical combined chemotherapy and radiation therapy regimen for patients with primary germ cell tumors of the brain. After surgical debulking of the tumor and histological verification, patients were divided into three therapeutic groups: good prognosis, intermediate prognosis, and poor prognosis. Patients received two kinds of chemotherapy (three courses) prior to receiving radiation therapy: carboplatin-etoposide combination ([CARB-VP]: carboplatin 450 mg/m(2) on Day 1, etoposide 150 mg/m(2) on Days 1-3) or ifosphamide-cisplatin-etoposide combination ([ICE]: ifosphamide 900 mg/m(2), cisplatin 20 mg/m(2), and etoposide 60 mg/m(2) on Days 1-5). Patients in the good prognosis group (those with germinomas) were treated with CARB-VP followed by local radiation therapy (24 Gy). Patients in the intermediate prognosis group received CARB-VP followed by local radiation therapy (50 Gy); they received five additional chemotherapy treatments. Patients in the poor prognosis group received ICE followed by whole craniospinal radiation therapy; they also received five additional chemotherapy treatments. Eighty-two patients were evaluated. For the 56 patients with germinomas, a 93% rate of complete remission after treatment was achieved. The remission rate was 76% for 21 patients in the intermediate prognosis group, and no recurrence was detected during a median follow-up period of 2.6 years. In the group of five patients with poor prognosis, the disease in three patients progressed during chemotherapy or radiation therapy and they died within 6 months. There were no serious complications in the surviving patients. The authors found their treatment protocols to be currently effective for patients with germinomas and those with an intermediate prognosis.
鞍上生殖细胞瘤（异位松果体瘤）：复发性疾病中免疫学特征和成功化疗反应的方面。
影响因子：
4.8
作者：
Neuwelt,EA;Frenkel,EP;Smith,RG
通讯作者：
Smith,RG