Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles.
Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles.
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DOI：
10.1186/s13618-015-0035-1
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发表时间：
2015
影响因子：
2.9
通讯作者：
Ohno K
中科院分区：
文献类型：
--
作者：
Ichihara M;Sobue S;Ito M;Ito M;Hirayama M;Ohno K
自2007年以来，人们一直在研究分子氢对各种疾病模型和人类疾病的治疗作用。从2007年到2015年6月，共发表了321篇原创文章。大多数研究在日本、中国和美国进行。大约四分之三的文章显示了对小鼠和大鼠的影响。临床试验的数量每年都在增加。在大多数疾病中，氢的作用已被氢水或氢气报道，随后证实了富氢盐水的作用。氢水主要是自由饮用。通过吸入给出小于4%的氢气。这些影响已在基本上所有器官中报告，涵盖31种疾病类别，可细分为166种疾病模型、人类疾病、治疗相关病理和植物病理生理状况，其中以氧化应激介导的疾病和炎性疾病为主。羟基自由基和过氧亚硝酸盐的具体的清除最初提出，但自由基清除作用的氢不能单独负责其激烈的影响。我们和其他人已经表明，这种作用可以通过调节各种分子的活性和表达来介导，如林恩、ERK、p38、JNK、ASK 1、Akt、GTP-Rac 1、iNOS、Nox 1、NF-κB p65、IκBα、STAT 3、NFATc 1、c-Fos和ghrelin。然而，驱动这些修改的主调节器仍有待阐明，目前正在进行广泛的研究。
Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. About three-quarters of the articles show the effects in mice and rats. The number of clinical trials is increasing every year. In most diseases, the effect of hydrogen has been reported with hydrogen water or hydrogen gas, which was followed by confirmation of the effect with hydrogen-rich saline. Hydrogen water is mostly given ad libitum. Hydrogen gas of less than 4 % is given by inhalation. The effects have been reported in essentially all organs covering 31 disease categories that can be subdivided into 166 disease models, human diseases, treatment-associated pathologies, and pathophysiological conditions of plants with a predominance of oxidative stress-mediated diseases and inflammatory diseases. Specific extinctions of hydroxyl radical and peroxynitrite were initially presented, but the radical-scavenging effect of hydrogen cannot be held solely accountable for its drastic effects. We and others have shown that the effects can be mediated by modulating activities and expressions of various molecules such as Lyn, ERK, p38, JNK, ASK1, Akt, GTP-Rac1, iNOS, Nox1, NF-κB p65, IκBα, STAT3, NFATc1, c-Fos, and ghrelin. Master regulator(s) that drive these modifications, however, remain to be elucidated and are currently being extensively investigated.