Cortical domains and the mechanisms of asymmetric cell division
Cortical domains and the mechanisms of asymmetric cell division
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DOI：
10.1016/0962-8924(96)10035-0
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发表时间：
1996-10-01
影响因子：
19
通讯作者：
Hyman, AA
中科院分区：
文献类型：
--
作者：
Gonczy, P;Hyman, AA
不对称的细胞分裂是细胞命运多样性产生的核心，因为母细胞中存在的并在细胞分裂时不均匀分布的因子可以产生不同的子代。不对称细胞分裂的过程可以描述为由三个步骤组成：在母细胞中建立不对称的nle，相对于该线索定位因子，以及定位细胞分裂平面，使得定位因子在子细胞之间不对称地分配。这篇综述介绍了如何专门的皮质域发挥关键作用，在这些步骤中的每一个，并讨论了我们目前的理解皮质域的分子性质和机制，他们可能编排不对称的细胞分裂。
Asymmetric cell divisions are central to the generation of cell-fate diversity because factors that are present in a mother cell and distributed unequally at cell division can generate distinct daughters. The process of asymmetric cell division can be described as consisting of three steps: setting up an asymmetric nle in the mother cell, localizing factors with respect to this cue, and positioning the plane of cell division so that localized factors are partitioned assymetrically between daughters. This review describes how specialized cortical domains play a key role in each of these steps and discusses our current understanding of the molecular nature of cortical domains and the mechanisms by which they may orchestrate asymmetric cell divisions.