The effect of souvenaid on functional brain network organisation in patients with mild Alzheimer's disease: a randomised controlled study.
The effect of souvenaid on functional brain network organisation in patients with mild Alzheimer's disease: a randomised controlled study.
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DOI：
10.1371/journal.pone.0086558
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
van Straaten EC
中科院分区：
文献类型：
--
作者：
de Waal H;Stam CJ;Lansbergen MM;Wieggers RL;Kamphuis PJ;Scheltens P;Maestú F;van Straaten EC
突触丢失是阿尔茨海默病（AD）的主要标志。AD中大规模功能性脑网络的组织紊乱可能反映了突触丢失和神经元通信中断。含有特定营养组合Fortasyn Connect的医疗食品Souvenaid旨在增强突触形成和功能，并在两项随机对照试验中显示可改善轻度AD患者的记忆表现。在轻度AD患者中，探索Souvenaid与对照产品相比对基于脑活动的网络（作为潜在突触功能的衍生物）的影响。一项为期24周的随机、对照、双盲、平行组、多国研究。179名参与Souvenir II研究的药物初治轻度AD患者。患者以1∶1的比例随机接受Souvenaid或等热量控制产品，每日一次，持续24周。在纪念品II研究的二次分析中，构建了脑电图（EEG）大脑网络，并使用图论来量化复杂的大脑结构。在研究组之间比较了局部脑网络连接（归一化聚类系数γ）和全局网络整合（归一化特征路径长度λ），并与记忆性能相关。两组之间的β频段网络测量值存在显著差异：对照组的网络测量值下降，但活动组的网络测量值保持相对不变。没有一致的关系，发现这些网络措施和内存性能。目前的结果表明，Souvenaid在24周内保留了轻度AD患者的大脑网络组织，假设抵消了AD中随时间推移的渐进性网络中断。这些结果加强了Souvenaid影响突触完整性和功能的假设。其次，我们得出结论，先进的脑电图分析，使用图论的数学框架，是有用的和可行的评估干预措施的效果。荷兰试验注册NTR 1975。
Synaptic loss is a major hallmark of Alzheimer’s disease (AD). Disturbed organisation of large-scale functional brain networks in AD might reflect synaptic loss and disrupted neuronal communication. The medical food Souvenaid, containing the specific nutrient combination Fortasyn Connect, is designed to enhance synapse formation and function and has been shown to improve memory performance in patients with mild AD in two randomised controlled trials. To explore the effect of Souvenaid compared to control product on brain activity-based networks, as a derivative of underlying synaptic function, in patients with mild AD. A 24-week randomised, controlled, double-blind, parallel-group, multi-country study. 179 drug-naïve mild AD patients who participated in the Souvenir II study. Patients were randomised 1∶1 to receive Souvenaid or an iso-caloric control product once daily for 24 weeks. In a secondary analysis of the Souvenir II study, electroencephalography (EEG) brain networks were constructed and graph theory was used to quantify complex brain structure. Local brain network connectivity (normalised clustering coefficient gamma) and global network integration (normalised characteristic path length lambda) were compared between study groups, and related to memory performance. The network measures in the beta band were significantly different between groups: they decreased in the control group, but remained relatively unchanged in the active group. No consistent relationship was found between these network measures and memory performance. The current results suggest that Souvenaid preserves the organisation of brain networks in patients with mild AD within 24 weeks, hypothetically counteracting the progressive network disruption over time in AD. The results strengthen the hypothesis that Souvenaid affects synaptic integrity and function. Secondly, we conclude that advanced EEG analysis, using the mathematical framework of graph theory, is useful and feasible for assessing the effects of interventions. Dutch Trial Register NTR1975.
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影响因子：
4.3
作者：
de Haan W;Mott K;van Straaten EC;Scheltens P;Stam CJ
通讯作者：
Stam CJ
DOI：
10.1177/155005949502600107
发表时间：
1995-01-01
期刊：
CLINICAL ELECTROENCEPHALOGRAPHY
影响因子：
--
作者：
DUNKIN, JJ;OSATO, S;LEUCHTER, AF
通讯作者：
LEUCHTER, AF
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
DOI：
10.1073/pnas.89.5.1671
发表时间：
1992-03-01
影响因子：
11.1
作者：
NITSCH, RM;BLUSZTAJN, JK;WURTMAN, RJ
通讯作者：
WURTMAN, RJ
影响因子：
2.5
作者：
AERTSEN, AMHJ;GERSTEIN, GL;PALM, G
通讯作者：
PALM, G