Copper-diamine-catalyzed N-arylation of pyrroles, pyrazoles, indazoles, imidazoles, and triazoles
Copper-diamine-catalyzed N-arylation of pyrroles, pyrazoles, indazoles, imidazoles, and triazoles
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DOI：
10.1021/jo049658b
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发表时间：
2004-08-20
影响因子：
3.6
通讯作者：
Buchwald, SL
中科院分区：
文献类型：
--
作者：
Antilla, JC;Baskin, JM;Buchwald, SL
本文详细介绍了铜催化的π-过量氮杂环的N-芳基化反应。芳基碘或芳基溴与常见的氮杂环（吡咯，吡唑，吲唑，咪唑和三唑）的偶联成功地进行了良好的产率与二胺配体和CuI衍生的催化剂。一般条件下，发现容忍官能团，如醛，酮，醇，伯胺，和腈的芳基卤或杂环。使用本文报道的条件，还发现卤代芳基卤化物或杂环是合适的底物。
This paper details the copper-catalyzed N-arylation of pi-excessive nitrogen heterocycles. The coupling of either aryl iodides or aryl bromides with common nitrogen heterocycles (pyrroles, pyrazoles, indazoles, imidazoles, and triazoles) was successfully performed in good yield with catalysts derived from diamine ligands and CuI. General conditions were found that tolerate functional groups such as aldehydes, ketones, alcohols, primary amines, and nitriles on the aryl halide or heterocycle. Hindered aryl halides or heterocycles were also found to be suitable substrates using the conditions reported herein.