TELENCEPHALIC PROJECTIONS OF THE A8 DOPAMINE CELL GROUP
TELENCEPHALIC PROJECTIONS OF THE A8 DOPAMINE CELL GROUP
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DOI：
10.1111/j.1749-6632.1988.tb42095.x
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发表时间：
1988-10-15
影响因子：
5.2
通讯作者：
ROTH, RH
中科院分区：
文献类型：
--
作者：
DEUTCH, AY;GOLDSTEIN, M;ROTH, RH
用顺行和逆行-免疫组织化学相结合的方法研究了大鼠A8多巴胺细胞组的端脑投射。A8神经元对前脑的投射比迄今所知的更广泛，包括纹状体、边缘和分配皮质区域。结果表明，A8神经元参与纹状体、伏隔核、嗅结节、杏仁核和终纹床核的多巴胺能神经支配，也参与梨状皮质和内嗅皮质的神经支配。此外，还观察到中脑内的投射，提示A8、A9和A10细胞组的多巴胺能神经元之间可能存在直接的相互联系。因此，这些数据表明，A8多巴胺细胞群在调节黑质纹状体和中脑皮质边缘区域的功能活动方面具有独特的位置，并进一步表明，中脑多巴胺神经元的异质性嵌入了一个更大的均一中脑多巴胺系统。
The telencephalic projections of the A8 dopamine cell group of the rat were assessed using both anterograde and combined retrograde-immunohistochemical methods. The projections of the A8 neurons onto the forebrain were more extensive than hitherto realized, and encompassed striatal, limbic, and allocortical regions. The A8 neurons were shown to contribute to the dopaminergic innervation of the striatum, nucleus accumbens, olfactory tubercles, amygdala, and bed nucleus of the stria terminalis, and also innervate the pyriform and entorhinal cortices. In addition, projections within the midbrain were observed, and suggested that there may be direct interconnections between the dopaminergic neurons of the A8, A9, and A10 cell groups. These data therefore suggest that the A8 dopamine cell group is uniquely situated to modulate functional activity within both nigrostriatal and mesocorticolimbic regions, and further suggests that heterogeneities of the midbrain dopamine neurons are embedded within a larger homogeneous mesotelencephalic dopamine system.