Isolation and characterization of a human novel RAB (RAB39B) gene
Isolation and characterization of a human novel RAB (RAB39B) gene
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DOI：
10.1159/000064047
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发表时间：
2002-01-01
影响因子：
1.7
通讯作者：
Mao, Y
中科院分区：
文献类型：
--
作者：
Cheng, H;Ma, Y;Mao, Y
RAB蛋白是一种小分子GTP酶，控制着真核细胞中的囊泡运输。在对人胎脑cDNA文库进行大规模测序分析的过程中，我们分离到一个编码新的Rab蛋白的cDNA克隆，该克隆与先前分离的Rab39A在氨基酸水平上有74.2%的同源性。RAB39B在人体多种组织中均有表达，定位于人类染色体Xq28。它由两个外显子组成，跨越3764bp的人类基因组DNA。版权所有(C)2002 S.Karger AG，巴塞尔。
Rab proteins are small-molecular-weight GTPases that control vesicular trafficking in eukaryotic cells. During the large-scale sequencing analysis of a human fetal brain cDNA library, we isolated a cDNA clone encoding a novel Rab protein, which showed 74.2% identity with previously isolated Rab39A at the amino acid level. RAB39B was expressed in a variety of human tissues and located in human chromosome Xq28. It consisted of two exons spanning 3764 bp of human genomic DNA. Copyright (C) 2002 S. Karger AG, Basel.