Tonotopic organization of the human auditory cortex as detected by BOLD-FMRI
Tonotopic organization of the human auditory cortex as detected by BOLD-FMRI
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DOI：
10.1016/s0378-5955(98)00139-7
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发表时间：
1998-12-01
期刊：
影响因子：
2.8
通讯作者：
Seelig, J
中科院分区：
文献类型：
--
作者：
Bilecen, D;Scheffler, K;Seelig, J
功能磁共振成像是一种非侵入性和非放射性的方法来检测局灶性脑活动。在本研究中的听觉皮层进行了调查，在9名正常人谁是双耳刺激使用500 Hz和4000 Hz的脉冲正弦音调。BOLD（血氧水平依赖性）信号变化与刺激范式一致，并在上级颞回平面检测到。激活区域的空间分布的比较揭示了两个频率的不同行为。本研究结果表明，在人类听觉皮层的两个半球的内侧，fi-to-ocipital和颅尾延伸存在一个频率特异性组织。高音调刺激的激活区比低音调刺激的激活区更多地位于前部和内侧。此外，在较高频率下观察到轻微的头尾移位，在右侧颞叶中比在左侧颞叶中更明显。最后，对于大多数受试者调查的BOLD激活面积的500 Hz的正弦音调大于4000 Hz的刺激。这两个频率都显示出信号响应对左颞叶的偏侧化。(C)1998 Elsevier Science B. V.保留所有权利。
Functional magnetic resonance imaging is a noninvasive and nonradioactive method for the detection of focal brain activity. In the present study the auditory cortex was investigated in nine normal subjects who were binaurally stimulated using pulsed sine tones of 500 Hz and 4000 Hz. The BOLD (blood oxygenation level dependent) signal change coincided with the stimulation paradigm and was detected in the plane of the superior temporal gyrus. The comparison of the spatial distribution of activated areas revealed a different behavior for the two frequencies. The present findings underline the existence of a frequency specific organization in the medic-lateral, fi-onto-occipital and cranio-caudal extension in both hemispheres of the auditory cortex in human. The activated areas for the high tone were found more frontally and medially orientated than the low tone stimulated areas. Furthermore, a slight cranio-caudal shift was observed for the higher frequency, more pronounced in the right than in the left temporal lobe. Finally, for most of the subjects investigated the BOLD activation area of the 500 Hz sine tone was larger than that of the 4000 Hz stimulation. Both frequencies showed a lateralization of signal response to the left temporal lobe. (C) 1998 Elsevier Science B.V. All rights reserved.