Copper and copper‐binding protein in fibrolamellar liver cell carcinoma
Copper and copper‐binding protein in fibrolamellar liver cell carcinoma
复制标题
纤维板层肝细胞癌中的铜和铜结合蛋白
作者：
J. Lefkowitch;R. Muschel;J. Price;C. Marboe;S. Braunhut
对最近一例纤维板层性肝细胞癌的组织进行了几种染色和分光光度分析，发现恶性肝细胞中铜和铜结合蛋白（CBP）升高。CBP的产生以前没有被描述为这种或任何其他类型的肝细胞癌。在肝细胞癌中发现CBP进一步证明该蛋白是肝细胞的正常合成产物，可能在慢性胆汁淤积或肝恶性肿瘤中再次出现。在这种情况下，铜稳态紊乱的机制尚不确定。
Analysis of tissue from a recent case of fibrolamellar liver cell carcinoma by several staining and spectrophotometrc methods demonstrated elevated copper and copper‐binding protein (CBP) in malignant hepatocytes. Production of CBP has not previously been described for this or any other type of hepatocellular carcinoma. Identification of CBP in liver cell carcinoma adds further evidence that this protein is a normal synthetic product of liver cells which may reappear in chronic cholestasis or hepatic malignancy. The mechanism of disturbed copper homeostasis in this case is uncertain.