DIFFERENTIATION OF NEURONS CONTAINING OLFACTORY MARKER PROTEIN IN ADULT-RAT OLFACTORY EPITHELIUM TRANSPLANTED TO THE ANTERIOR-CHAMBER OF THE EYE
DIFFERENTIATION OF NEURONS CONTAINING OLFACTORY MARKER PROTEIN IN ADULT-RAT OLFACTORY EPITHELIUM TRANSPLANTED TO THE ANTERIOR-CHAMBER OF THE EYE
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DOI：
10.1016/0306-4522(82)90092-6
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发表时间：
1982-01-01
期刊：
影响因子：
3.3
通讯作者：
ZIMMER, J
中科院分区：
文献类型：
--
作者：
BARBER, PC;JENSEN, S;ZIMMER, J
嗅觉标记蛋白是完全分化的嗅觉感觉神经元特有的细胞质成分。这种蛋白质的表达可能只有在神经元与中枢神经系统进行突触接触时才会发生。将成人嗅上皮作为自体移植物移植到眼前房。该过程破坏了成熟的感觉神经元，随后被干细胞的分裂和分化所取代。新形成的感觉神经元充分分化以产生嗅觉标记蛋白，而没有明显接触中枢神经组织。嗅觉标记蛋白的表达不需要与中枢神经系统接触。
Olfactory marker protein is a cytoplasmic component unique to fully-differentiated olfactory sensory neurons. Expression of this protein probably occurs only if the neurons make synaptic contact with the CNS. Adult olfactory epithelium was transplanted as an autograft to the anterior chamber of the eye. This procedure destroys the mature sensory neurons, which are subsequently replaced by division and differentiation of stem cells. The newly-formed sensory neurons differentiate sufficiently to produce olfactory marker protein, without apparently contacting central nervous tissue. Contact with the CNS is not necessary for expression of olfactory marker protein.