Sex Differences in Recombination in Sticklebacks.
Sex Differences in Recombination in Sticklebacks.
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DOI：
10.1534/g3.118.200166
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发表时间：
2018-05-31
期刊：
影响因子：
--
通讯作者：
Kirkpatrick M
中科院分区：
文献类型：
--
作者：
Sardell JM;Cheng C;Dagilis AJ;Ishikawa A;Kitano J;Peichel CL;Kirkpatrick M
重组往往在雄性和雌性之间有明显的差异。在这里，我们首次分析了刺鱼的性别特异性重组。通过对蓝棉和日本棉15个杂交组合的全基因组测序，我们定位了698个杂交组合，平均分辨率为2.3kb。我们还使用生物信息学的方法来推断这两个物种的历史性别平均重组模式。在所有染色体上，雌性的重组率都大于雄性，雌性的总图谱长度是雄性的1.64倍。交叉点的位置在不同性别之间有显著差异。在雄性中，交叉向染色体末端聚集，但在雌性中，交叉更均匀地分布在染色体上。雄性染色体着丝粒附近重组的抑制会导致交叉聚集在顶端着丝粒染色体的长臂末端，并极大地减少短臂的交叉。着丝粒对重组的影响在雌性中要弱得多。刺棉和日本棉的基因组分化与重组率密切相关，染色体上的分化模式受到雄性特有的端粒和着丝粒效应的强烈影响。我们没有发现任何证据表明重组和性别间的局部基因含量之间存在细微的相关性。我们讨论了重组中性二型性起源的假设及其对性拮抗选择和性染色体进化的影响。
Recombination often differs markedly between males and females. Here we present the first analysis of sex-specific recombination in Gasterosteus sticklebacks. Using whole-genome sequencing of 15 crosses between G. aculeatus and G. nipponicus, we localized 698 crossovers with a median resolution of 2.3 kb. We also used a bioinformatic approach to infer historical sex-averaged recombination patterns for both species. Recombination is greater in females than males on all chromosomes, and overall map length is 1.64 times longer in females. The locations of crossovers differ strikingly between sexes. Crossovers cluster toward chromosome ends in males, but are distributed more evenly across chromosomes in females. Suppression of recombination near the centromeres in males causes crossovers to cluster at the ends of long arms in acrocentric chromosomes, and greatly reduces crossing over on short arms. The effect of centromeres on recombination is much weaker in females. Genomic differentiation between G. aculeatus and G. nipponicus is strongly correlated with recombination rate, and patterns of differentiation along chromosomes are strongly influenced by male-specific telomere and centromere effects. We found no evidence for fine-scale correlations between recombination and local gene content in either sex. We discuss hypotheses for the origin of sexual dimorphism in recombination and its consequences for sexually antagonistic selection and sex chromosome evolution.
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DOI：
10.1098/rstb.2000.0717
发表时间：
2000-11-29
影响因子：
6.3
作者：
Charlesworth, B;Charlesworth, D
通讯作者：
Charlesworth, D
影响因子：
4.5
作者：
Auton A;Rui Li Y;Kidd J;Oliveira K;Nadel J;Holloway JK;Hayward JJ;Cohen PE;Greally JM;Wang J;Bustamante CD;Boyko AR
通讯作者：
Boyko AR
影响因子：
7
作者：
Backstrom, Niclas;Forstmeier, Wolfgang;Ellegren, Hans
通讯作者：
Ellegren, Hans
影响因子：
4.9
作者：
Berner, Daniel d;Roesti, Marius
通讯作者：
Roesti, Marius
影响因子：
7.7
作者：
Baker, Zachary;Schumer, Molly;Przeworski, Molly
通讯作者：
Przeworski, Molly