Burst activity of spiny projection neurons in the striatum encodes superimposed muscle tetani in cataleptic rats
Burst activity of spiny projection neurons in the striatum encodes superimposed muscle tetani in cataleptic rats
复制标题
DOI：
10.1007/s00221-003-1644-9
复制
发表时间：
2003-10-01
影响因子：
2
通讯作者：
Schmidt, WJ
中科院分区：
文献类型：
--
作者：
Frank, ST;Schmidt, WJ
动物的僵直症是一种运动障碍和肌肉高度僵硬的状态。僵直症是帕金森病的典型。纹状体中刺状投射神经元的活动与大鼠或灵长类动物的不同肌肉群有关。爆发活动是帕金森病状态下棘突神经元的典型特征。用0.5 mg/kg氟哌啶醇诱导大鼠进入催化状态180s。测量纹状体棘突神经元的活动，以检测棘突频率的变化。当大鼠在前肢肌肉已经存在的破伤风的基础上增加肌肉张力时，手动设置触发器。结果显示，发生的触发与纹状体的爆发活动有明显的相关性。在这种突发事件中，大鼠不动，但表现出这种典型的叠加性肌肉破伤风。一种可能的解释是，当运动的执行被阻止时，运动的意图被编码在纹状体的刺状投射神经元的爆发活动中。但也发生了与短期叠加性肌肉破伤风无关的爆发。
Catalepsy of animals represents a condition of akinesia and high rigidity of muscles. Catalepsy is a model for Parkinson's disease. The activity of spiny projection neurons in the striatum is correlated with different groups of muscles in rats or primates. Burst activity is a typical characteristic of spiny projection neurons in the state of Parkinson's disease. Rats were treated with 0.5 mg/kg haloperidol to induce a cataleptic state for 180 s. Spiny projection neuronal activity in striatum was measured to detect changes in spike frequency. Triggers were set manually when the rats increased their muscle tone superimposed on the already existing tetanus of the forelimb muscles. The results showed a clear correlation of the occurring triggers and the burst activity in the striatum. During such a burst event, rats did not move but showed this typical superimposed muscle tetanus. A possible explanation is that the intention to move is encoded in the burst activity of spiny projection neurons in the striatum while the execution of the movement is blocked. But also bursts that are not correlated with the short-term superimposed muscle tetanus occurred.