The relationship between stress during pregnancy with leptin and cortisol blood concentrations and complications of pregnancy in the mother
The relationship between stress during pregnancy with leptin and cortisol blood concentrations and complications of pregnancy in the mother
复制标题
妊娠期压力、瘦素和皮质醇血浓度与母亲妊娠并发症的关系
DOI：
10.4274/jtgga.galenos.2019.2019.0010
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
M. Abedi
中科院分区：
文献类型：
--
作者：
S. Rabiepour;E. Saboory;M. Abedi
目的：怀孕是女性一生中压力最大的时期之一。本研究试图确定孕期母体应激与皮质醇、母体血清瘦素浓度以及妊娠结局之间的关系。材料和方法：这项纵向研究于2015-2016年间对绵多阿布市90名孕妇进行。这些样本来自孕周在24到28周之间的母亲。参与者被要求完成科恩的感知压力量表(PSS)，并从他们身上提取人口统计学调查问卷和血液样本。然后，母亲们每隔四周跟踪一次，直到分娩，每次都被要求完成科恩的PSS，以及一份与母亲结局有关的问卷。同样，在分娩时采集了血样。数据分析采用SPSS16统计软件，采用描述性统计、皮尔逊相关系数和t检验等方法进行分析。结果：母体应激与子痫前期有显著相关性(p=0.008)。24-28周的早产与母体皮质醇浓度(p=0.015)、早产与母体分娩时的瘦素浓度(p=0.007)之间也存在显著的相关性。结论：妊娠和分娩作为身心应激事件，可影响妇女的生理和心理指标。因此，在怀孕期间，皮质醇和瘦素指数会随着应激下丘脑-垂体轴和自主神经系统的活动而变化。
Objective: Pregnancy is one of the most stressful periods a woman experiences in her life. The present study was an attempt to determine the relationship between maternal stress during pregnancy and cortisol plus maternal serum leptin concentrations as well as pregnancy outcomes. Material and Methods: This longitudinal study was conducted on 90 pregnant women in Miandoab city between 2015 and 2016. The samples were chosen from mothers with a gestational age of 24 to 28 weeks. The participants were asked to complete Cohen’s Perceived Stress Scale (PSS) and a demographic questionnaire and blood samples were taken from them. The mothers were then tracked with four-week intervals until the time of delivery and were asked to complete Cohen’s PSS each time along with a questionnaire related to maternal outcomes. Again, a blood sample was taken at the time of delivery. Data analysis was performed using SPSS 16. Descriptive statistics, Pearson’s correlation coefficient, and the t-test were employed for analysis. Results: A significant relationship was found between maternal stress and preeclampsia (p=0.008). The relationships between preterm childbirth and maternal cortisol concentrations in weeks 24-28 (p=0.015), and between preterm childbirth and maternal leptin concentrations at the time of delivery (p=0.007) were also found to be significant. Conclusion: Pregnancy and labor, as physically and mentally stressful events, can affect women’s physiologic and psychological indicators. As a consequence, during pregnancy, the cortisol and leptin index changes in response to the activity of the hypothalamic-pituitary axis and autonomic nervous system under stress.
影响因子：
9.8
作者：
Wadhwa, PD;Garite, TJ;Sandman, CA
通讯作者：
Sandman, CA
影响因子：
4.2
作者：
Glynn, Laura M.;Schetter, Christine Dunkel;Sandman, Curt A.
通讯作者：
Sandman, Curt A.