Precision and accuracy of bone mineral determination by direct photon absorptiometry.
Precision and accuracy of bone mineral determination by direct photon absorptiometry.
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DOI：
10.1097/00004424-196805000-00001
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发表时间：
1968-05-01
影响因子：
6.7
通讯作者：
Sorenson, J A
中科院分区：
文献类型：
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作者：
Cameron, J R;Mazess, R B;Sorenson, J A
骨矿物质测定采用放射吸收法。用准直闪烁探测器脉冲高度分析系统测量了来自准直良好的放射性核素源（125 I或241 Am）的低能束的衰减。如这种扫描方法所示，骨对光子束的吸收与切除骨标准切片的重量高度相关（r= 0.97至0.99）。甚至对覆盖尸体前臂的组织的扫描与潜在骨成分的重量高度相关（r= 0.96），对人尺骨的单次扫描与尺骨总重量高度相关（r= 0.96）。精密度（2%）和准确度（4至7%的误差）是有史以来最高的放射学方法的骨测定和大的不准确性（超过20至30%的误差）的老方法，使用光密度的射线照片，被消除了本方法。改进后的技术允许更高的精度（1 - 2%）和准确度（2 - 4%），因此，放射性核素吸收法是潜在的有用的诊断，临床和规范性评价approximular骨骼矿化旧的光密度测定方法不能使用。
Bone mineral was determined using a radiologic absorptiometric method. The attenuation of a low-energy beam from a well-collimated radionuclide source (125 I or 241 Am) was measured using a collimated scintillation detectorpulse height analyzer system. The absorption of the photon beam by bone, as shown by this scanning method, was highly correlated with the weight of standard sections on excised bones (r= 0.97 to 0.99). Even scans on tissue covered cadaver forearms were highly correlated (r= 0.96) with the weight of underlying bone components and single scans on human ulnae were highly correlated (r= 0.96) with total ulna weight. The precision (2%) and accuracy (4 to 7% error) were the highest ever demonstrated for a radiologic method of bone determination and the large inaccuracies (more than 20 to 30% error) of older methods, which used photodensitometry of radiographs, were eliminated by the present method. Improved techniques allow even higher precision (1 to 2%) and accuracy (2 to 4%); therefore, the radionuclide absorption method is potentially useful for diagnostic, clinical and normative evaluation of appendicular skeletal mineralization where older photodensitometric methods cannot be used.