Adiponectin and glucose production in patients infected with Plasmodium falciparum
Adiponectin and glucose production in patients infected with Plasmodium falciparum
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DOI：
10.1016/j.metabol.2004.07.011
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发表时间：
2005-01-01
影响因子：
9.8
通讯作者：
Sauerwein, HP
中科院分区：
文献类型：
--
作者：
Blümer, RME;van Thien, H;Sauerwein, HP
由于葡萄糖逆向调节激素和细胞因子的分泌受到刺激，导致葡萄糖产量增加，感染往往会变得更加复杂。脂联素是一种脂肪衍生的激素，具有胰岛素增敏特性，可以在感染因子刺激葡萄糖产生的程度中发挥调节作用。因此，我们调查了25名受试者：7名脑型疟疾患者、6名无并发症的疟疾患者和12名匹配的对照组中葡萄糖产生与血浆脂联素水平的可能相关性。疟疾患者的葡萄糖产生显著高于健康对照组(P<；.001)。疟疾患者与对照组的脂联素水平无明显差异。然而，脑型疟疾患者的脂联素水平显著高于无并发症的疟疾患者(P&t；.005)。脑型疟疾患者的糖生成和糖异生与血浆脂联素水平呈正相关(r=0.835，P&t；.001和r=0.846，P&t；.001)，而在对照组中不存在这种相关性(r=-0.329，N S和r=-0.028，N S)。然而，葡萄糖产量较高的恶性疟原虫感染患者的脂联素水平也较高。在健康受试者中没有发现这种相关性。由于已知脂联素可以抑制葡萄糖的产生，因此在感染期间刺激脂联素的分泌可能是为了抑制葡萄糖的产生，刺激激素和细胞因子在感染期间分泌的特性。(C)2004 Elsevier Inc.保留所有权利。
Infections are often complicated by an increase in glucose production due to stimulation of the secretion of glucose counter-regulatory hormones and cytokines. Adiponectin, a fat-derived hormone with insulin-sensitizing properties, could play a regulatory role in the degree of stimulation of glucose production by the infectious agent. Therefore, we investigated the possible correlation between glucose production and plasma adiponectin levels in 25 subjects: 7 patients with cerebral malaria, 6 with uncomplicated malaria, and 12 matched controls.Glucose production was significantly higher in patients with malaria compared to healthy controls (P < .001). Adiponectin levels were not different between the patients with malaria and the control group. However, patients with cerebral malaria had significantly higher values for adiponectin than the patients with uncomplicated malaria (P < .005).Glucose production and gluconeogenesis were positively correlated to plasma adiponectin in the patients (r = 0.835, P < .001 and r = 0.846, P < .001, respectively), whereas these correlations were absent in the controls (r = -0.329, NS and r = -0.028, NS, respectively).In conclusion, adiponectin levels were not different between patients with malaria and their matched controls. However, patients infected with Plasmodium falciparum who have higher glucose production also have higher adiponectin levels. In healthy subjects such a correlation was not found.As adiponectin is known to inhibit glucose production, stimulation of adiponectin secretion during infection could be intended to restrain the glucose production stimulating properties of hormones and cytokines secreted during infection. (c) 2004 Elsevier Inc. All rights reserved.