C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration.
C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration.
复制标题
DOI：
10.1016/j.ophtha.2009.11.020
复制
发表时间：
2010-08
期刊：
影响因子：
13.7
通讯作者：
Rosner B
中科院分区：
文献类型：
--
作者：
Seddon JM;Gensler G;Rosner B
遗传变异CFH和ARMS 2/HTRA 1基因区域以及高敏C反应蛋白（CRP）水平与年龄相关性黄斑变性（AMD）有关。我们评估了它们对AMD风险的独立和综合影响，以及它们的相互作用。病例对照研究。年龄相关眼病辅助研究中患有AMD（n = 244）或无黄斑病变或极轻微黄斑病变（n = 209）的受试者。通过问卷调查、直接测量和血液标本分析评估风险因素、基因型和生物标志物。使用logistic回归分析评估血清CRP和CFH（rs 1061170）和ARMS 2/HTRA 1（rs 10490924）基因型的独立和联合作用，调整年龄，性别，教育，吸烟，体重指数和维生素/矿物质补充。我们将AMD定义为大玻璃疣、地图状萎缩或新生血管性疾病。控制基因型、人口统计学和行为危险因素后，较高的CRP水平与较高的AMD风险相关，3.0 mg/L及以上与1.0 mg/L以下的比值比为2.6（95%置信区间，1.01-6.7）。两个基因的单核苷酸多态性（SNPs）也与AMD的风险独立相关，控制CRP水平和其他因素。两种最高水平CRP的存在以及两种SNP的风险基因型赋予AMD的最高风险（OR 5.4，95%CI 1.4-21.1）。高敏CRP和CFH和ARMS 2/HTRA 1基因多态性与AMD风险独立相关。在大多数基因型组中，较高的CRP水平倾向于赋予较高的AMD风险。
Genetic variants CFH and ARMS2/HTRA1 gene regions as well as high-sensitivity C-reactive protein (CRP) levels are related to age-related macular degeneration (AMD). We evaluated their independent and combined effects on risk of AMD, as well as their interactions. Case-control study. Subjects with AMD (n = 244) or no or minimal maculopathy (n = 209) in the Age Related Eye Disease Ancillary Study. Risk factors, genotypes, and biomarkers were assessed by questionnaire, direct measurement, and analyses of blood specimens. The independent and joint effects of serum CRP and CFH (rs1061170) and ARMS2/HTRA1 (rs10490924) genotypes were assessed using logistic regression analyses, adjusting for age, gender, education, smoking, body mass index, and vitamin/mineral supplementation. We defined AMD as large drusen, geographic atrophy, or neovascular disease. Higher CRP levels were associated with a higher risk of AMD, controlling for genotype and demographic and behavioral risk factors, with odds ratio 2.6 for levels of 3.0 mg/L and above versus below 1.0 mg/L (95% confidence interval, 1.01–6.7). Single nucleotide polymorphisms (SNPs) in both genes were also independently associated with risk of AMD, controlling for the level of CRP and other factors. Presence of both highest level of CRP together with risk genotypes for both SNPs, conferred the highest risk of AMD (OR 5.4, 95% CI 1.4–21.1). High-sensitivity CRP and polymorphisms in the CFH and ARMS2/HTRA1 genes are independently associated with risk of AMD. Higher CRP level tends to confer a higher risk of AMD within most genotype groups.
登录
查看更多内容
DOI：
10.1073/pnas.0501536102
发表时间：
2005-05-17
影响因子：
11.1
作者：
Hageman, GS;Anderson, DH;Allikmets, R
通讯作者：
Allikmets, R
影响因子：
--
作者：
Kassoff, A;Kassoff, J;Chew, EY
通讯作者：
Chew, EY
影响因子：
5.2
作者：
Fagerness, Jesen A.;Maller, Julian B.;Seddon, Johanna M.
通讯作者：
Seddon, Johanna M.
影响因子：
4.4
作者：
Reynolds R;Hartnett ME;Atkinson JP;Giclas PC;Rosner B;Seddon JM
通讯作者：
Seddon JM
影响因子：
56.9
作者：
Edwards, AO;Ritter, R;Farrer, LA
通讯作者：
Farrer, LA