THIAMINE, RIBOFLAVIN AND PYRIDOXINE-DEFICIENCY IN PSYCHIATRIC-INPATIENTS
THIAMINE, RIBOFLAVIN AND PYRIDOXINE-DEFICIENCY IN PSYCHIATRIC-INPATIENTS
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DOI：
10.1192/bjp.141.3.271
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发表时间：
1982-01-01
影响因子：
10.5
通讯作者：
WILLIAMS, DG
中科院分区：
文献类型：
--
作者：
CARNEY, MWP;RAVINDRAN, A;WILLIAMS, DG
对地区综合医院精神病科连续入院的172人进行了检查。常规的精神病史、药物史和饮食史被记录下来，并特别注意到了维生素B中毒的迹象。检测红细胞转酮醇酶(硫胺素缺乏症)、谷胱甘肽还原酶(核黄素缺乏症)和天冬氨酸转氨酶(吡哆醇缺乏症)。在这些患者中，53%的人缺乏至少一种维生素，12%的人缺乏一种以上的维生素(30%的硫胺素，27%的核黄素和9%的吡哆醇)。精神分裂症和酗酒者在那些硫胺素和一种以上维生素含量较低的患者中比例明显偏高。情感性精神障碍患者核黄素和吡哆醇水平较低。提示情志改变以核黄素和吡哆醇缺乏为特征。
Successive admissions (172) to a district general hospital psychiatric unit were examined. Routine psychiatric, drug and dietary histories were taken and signs of avitaminosis B specifically noted. Red cell transketolase (for thiamin deficiency), glutathione reductase (for riboflavin deficiency) and aspartate transaminase (for pyridoxine deficiency) were measured. Of the patients, 53% were deficient in at least one vitamin, 12% in more than one (30% in thiamin, 27% in riboflavin and 9% in pyridoxine). Schizophrenics and alcoholics were significantly overrepresented in those patients low in thiamin and in more than one vitamin. Patients with an affective disorder had low riboflavin and low pyridoxine. It is suggested that affective changes are characteristic of riboflavin and pyridoxine deficiency.