Wireless and Catheter-Free Bladder Pressure and Volume Sensor.
Wireless and Catheter-Free Bladder Pressure and Volume Sensor.
复制标题
无线、无导管膀胱压力和容量传感器。
DOI：
10.1109/jsen.2023.3267749
复制
发表时间：
2024
影响因子：
4.3
通讯作者：
Damaser,MargotS
中科院分区：
文献类型：
--
作者：
Majerus,SteveJA;Hanzlicek,Brett;Hacohen,Yaneev;Cabal,Dario;Bourbeau,Dennis;Damaser,MargotS
在正常日常活动期间持续监测膀胱活动将改善临床诊断和对膀胱功能潜在机制的理解，或帮助验证不同的神经调节策略如何影响膀胱。这项工作描述了一个泌尿监测意识活动（UroMOCA）。UroMOCA包括压力传感器、尿阻抗传感电极、无线电池充电和数据传输电路。将组件组装在电路板上，并使用环氧树脂/硅胶模塑包装进行封装，允许Pt-Ir电极馈通用于尿液接触。包装的UroMOCA测量值mm。UroMOCA在30 cm范围内以10 Hz的频率连续传输来自所有机载传感器的数据，并在无线充电之间运行长达44 h。在体外校准后，在11只动物中进行校准。动物携带该装置28天，使许多观察膀胱行为在自然，有意识的行为。体内试验证实，UroMOCA在两周愈合期后不影响膀胱功能。体内压力数据与麻醉随访期间使用的参考导管高度相关。静态容量传感器数据不太准确，但证明了膀胱容量减少的可靠检测，并区分了排尿和非排尿膀胱事件。
Continuous monitoring of bladder activity during normal daily activities would improve clinical diagnostics and understanding of the mechanisms underlying bladder function, or help validate how differing neuromodulation strategies affect the bladder. This work describes a urological monitor of conscious activity (UroMOCA). The UroMOCA included a pressure sensor, urine impedance-sensing electrodes, and wireless battery recharge and data transmission circuitry. Components were assembled on a circuit board and encapsulated with an epoxy/silicone molded package that allowed Pt-Ir electrode feedthrough for urine contact. Packaged UroMOCAs measuredmm. UroMOCAs continuously transmitted data from all onboard sensors at 10 Hz at a 30 cm range, and ran for up to 44 h between wireless recharges. After in vitro calibration, implantations were performed in 11 animals. Animals carried the device for 28 days, enabling many observations of bladder behavior during natural, conscious behavior. In vivo testing confirmed the UroMOCA did not impact bladder function after a two-week healing period. Pressure data in vivo were highly correlated with a reference catheter used during an anesthetized follow-up. Static volume sensor data were less accurate, but demonstrated reliable detection of bladder volume decreases, and distinguished between voiding and non-voiding bladder events.