Decreased expression of G-protein-coupled receptors GPR43 and GPR109a in psoriatic skin can be restored by topical application of sodium butyrate
Decreased expression of G-protein-coupled receptors GPR43 and GPR109a in psoriatic skin can be restored by topical application of sodium butyrate
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DOI：
10.1007/s00403-018-1865-1
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发表时间：
2018-11-01
影响因子：
3
通讯作者：
Schwarz, Agatha
中科院分区：
文献类型：
--
作者：
Krejner, Alicja;Bruhs, Anika;Schwarz, Agatha
已知G蛋白偶联受体GPR43和GPR109a在肠道抗炎和抗癌功能中发挥重要作用。短链脂肪酸，如丁酸钠(SB)，是GPR43和GPR109a的激活剂，从而促进抗炎作用。本研究旨在检测这些受体在银屑病中的表达及其对SB的反应。取6例银屑病患者皮损和4例正常对照皮损和非皮损组织，进行GPR109a和GPR43染色。用SB对新鲜的活检材料进行体外刺激。银屑病皮损和非皮损皮肤角质形成细胞上GPr109a和GPR43的表达均低于对照皮肤。局部应用SB可增加这两种受体的低水平表达。提示SB通过恢复受损的GPR109a和GPR43的表达可能发挥抗炎作用，并可能被用作银屑病的外用工具，这一点有待未来的临床试验证明。
The G-protein-coupled receptors GPR43 and GPR109a are known to play an important role in mediating anti-inflammatory and anti-cancer functions in the gut. Short-chain fatty acids, such as sodium butyrate (SB), are activators of GPR43 and GPR109a and thereby promote anti-inflammatory effects. The present study aimed to examine the expression of these receptors and their reaction to SB in psoriasis. Lesional and non-lesional biopsies of 6 psoriasis patients and of 4 controls were obtained and stained for GPR109a and GPR43. Ex vivo stimulation with SB was performed on fresh biopsy material. Lesional and non-lesional psoriatic skin showed a decreased expression of GPR109a and GPR43 on keratinocytes in comparison with control skin. Topical application of SB was able to increase the low-level expression of both receptors. The data suggest that SB by restoring the impaired expression of GPR109a and GPR43 might exert anti-inflammatory effects and may be utilized as a topical tool for the treatment of psoriasis, which has to be proven in future clinical trials.