Tissue-specific expression of a type I adenylyl cyclase rescues the rutabaga mutant memory defect:: In search of the engram
Tissue-specific expression of a type I adenylyl cyclase rescues the rutabaga mutant memory defect:: In search of the engram
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DOI：
10.1101/lm.7.1.18
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发表时间：
2000-01-01
影响因子：
2
通讯作者：
Heisenberg, M
中科院分区：
文献类型：
--
作者：
Zars, T;Wolf, R;Heisenberg, M
大多数试图在中枢神经系统（CNS）中定位记忆的物理相关性的尝试都依赖于消融技术。这种方法的局限性在于只定义了记忆形成所需的未知数量的结构中的一个。我们使用果蝇I型Ca 2 +/CaM依赖性腺苷酸环化酶（AC）基因来确定哪个中枢神经系统区域AC表达足以形成记忆。使用GAL 4二进制转录激活系统的泛神经和限制性CNS表达，我们已经挽救了快速强大的空间学习范例中的芜菁甘蓝突变体的记忆缺陷。腹神经节、触角叶和中间束可能是足够用于芜菁AC依赖性空间学习的CNS结构。
Most attempts to localize physical correlates of memory in the central nervous system (CNS) rely on ablation techniques. This approach has the limitation of defining just one of an unknown number of structures necessary for memory formation. We have used the Drosophila rutabaga type I Ca2+/CaM-dependent adenylyl cyclase (AC) gene to determine in which CNS region AC expression is sufficient for memory formation. Using pan-neural and restricted CNS expression with the GAL4 binary transcription activation system, we have rescued the memory defect of the rutabaga mutant in a fast robust spatial learning paradigm. The ventral ganglion, antennal lobes, and median bundle are likely the CNS structures sufficient for rutabaga AC- dependent spatial learning.