Chromatin Dynamics of Circadian Transcription.
Chromatin Dynamics of Circadian Transcription.
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DOI：
10.1007/s40610-015-0001-7
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Sassone-Corsi P
中科院分区：
文献类型：
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作者：
Aguilar-Arnal L;Sassone-Corsi P
分子生物钟协调成千上万个基因的日常周期性表达。这种转录程序的破坏导致多种病理学，包括失眠、抑郁和代谢紊乱。基因表达的昼夜节律依赖于特定的染色质转换，最终由分子钟协调。因此，可以在不同的组织和细胞类型中描绘出高度可塑性和动态的昼夜节律表观基因组。有趣的是，基因组拓扑结构似乎在昼夜节律相互作用组协调循环转录，其中昼夜节律基因以时间特异性方式在细胞核内进行物理接触。此外，生物钟机制与关键的代谢调节因子有功能性相互作用，从而将昼夜表观基因组与细胞代谢联系起来。解开这种相互作用的分子方面可能会揭示新的治疗策略，对代谢紊乱的治疗。
The molecular circadian clock orchestrates the daily cyclical expression of thousands of genes. Disruption of this transcriptional program leads to a variety of pathologies, including insomnia, depression and metabolic disorders. Circadian rhythms in gene expression rely on specific chromatin transitions which are ultimately coordinated by the molecular clock. As a consequence, a highly plastic and dynamic circadian epigenome can be delineated across different tissues and cell types. Intriguingly, genome topology appears to coordinate cyclic transcription at circadian interactomes, in which circadian genes are in physical contact within the cell nucleus in a time-specific manner. Moreover, the clock machinery shows functional interplays with key metabolic regulators, thereby connecting the circadian epigenome to cellular metabolism. Unraveling the molecular aspects of such interplays is likely to reveal new therapeutic strategies towards the treatment of metabolic disorders.