Cingulo-opercular network efficiency mediates the association between psychotic-like experiences and cognitive ability in the general population.
Cingulo-opercular network efficiency mediates the association between psychotic-like experiences and cognitive ability in the general population.
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DOI：
10.1016/j.bpsc.2016.03.009
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发表时间：
2016-11
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精神病被假设发生在精神障碍和健康个体之间的一个谱上。在光谱的中间是那些支持精神病样经历（PLEs）的人，这些经历可能不会影响日常功能或造成痛苦。患有PLEs的个体在认知能力和几个大脑网络的功能连接方面都表现出改变，但PLEs，认知和功能网络之间的关系仍然知之甚少。我们分析了人类连接组项目中468名个体的静息状态fMRI数据、一系列神经心理学任务和Achenbach成人自我报告（ASR）中的问题。我们的目的是确定支持高阶认知的特定功能脑网络（额顶叶网络（FPN），扣带-鳃盖网络（CON）和默认模式网络（DMN））的整体效率是否与非精神病样本中的PLEs和认知能力相关。在我们的样本中，21.6%的人支持至少一个PLE。PLEs与高阶认知能力、CON整体效率和DMN整体效率呈显著负相关，但与结晶知识无关。高阶认知与CON和DMN整体效率显著正相关。有趣的是，PLEs和认知能力之间的关联部分由CON整体效率介导，并且在一个药物测试阴性的个体子集（N=405）中，右前额叶（CON内的枢纽）的参与系数。这些研究结果表明，CON完整性可能代表了一种共同的机制，赋予精神病经历的风险和在精神病谱系中观察到的认知缺陷。
Psychosis is hypothesized to occur on a spectrum between psychotic disorders and healthy individuals. In the middle of the spectrum are individuals who endorse psychotic-like experiences (PLEs) that may not impact daily functioning or cause distress. Individuals with PLEs show alterations in both cognitive ability and functional connectivity of several brain networks, but the relationship between PLEs, cognition, and functional networks remains poorly understood. We analyzed resting-state fMRI data, a range of neuropsychological tasks, and questions from the Achenbach Adult Self Report (ASR) in 468 individuals from the Human Connectome Project. We aimed to determine whether global efficiency of specific functional brain networks supporting higher-order cognition (the fronto-parietal network (FPN), cingulo-opercular network (CON), and default mode network (DMN)) was associated with PLEs and cognitive ability in a non-psychiatric sample. 21.6% of individuals in our sample endorsed at least one PLE. PLEs were significantly negatively associated with higher-order cognitive ability, CON global efficiency, and DMN global efficiency, but not crystallized knowledge. Higher-order cognition was significantly positively associated with CON and DMN global efficiency. Interestingly, the association between PLEs and cognitive ability was partially mediated by CON global efficiency and, in a subset of individuals who tested negative for drugs (N=405), the participation coefficient of the right anterior insula (a hub within the CON). These findings suggest that CON integrity may represent a shared mechanism that confers risk for psychotic experiences and the cognitive deficits observed across the psychosis spectrum.