Nucleotide sequence of the 5' noncoding region of hepatitis G virus isolated from Japanese patients: Comparison with reported isolates
Nucleotide sequence of the 5' noncoding region of hepatitis G virus isolated from Japanese patients: Comparison with reported isolates
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DOI：
10.1006/bbrc.1996.1353
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发表时间：
1996-09-13
影响因子：
3.1
通讯作者：
Katayama, K
中科院分区：
文献类型：
--
作者：
Fukushi, S;Kurihara, C;Katayama, K
The nucleotide sequences of the 5' noncoding region (NCR) of hepatitis G virus (HGV) from sera of Japanese patients were determined. Among these isolates, there was a high degree (>96.9%) of sequence identity, whereas identity with previously reported GB virus-C or HGV strains was low (>87.0%). Phylogenetic analyses showed that the HGV strains from Japanese patients clustered in groups distantly separated from previously reported strains. Among the Japanese HGV isolates, the genetic distances corresponded to subtype differences observed within hepatitis C virus (HCV) isolates, whereas the differences between the Japanese isolates and the prototypes corresponded to genetic distances observed between HCV genotypes. The Japanese HGV isolates found in this study should be placed in a new genotype distinct from previously described isolates. (C) 1996 Academic Press, Inc.
