Monoclonal Antibodies to Skeletal Muscle Cell Surface
Monoclonal Antibodies to Skeletal Muscle Cell Surface
复制标题
骨骼肌细胞表面单克隆抗体
DOI：
10.1007/978-1-4684-4190-1_2
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
R. Rotundo
中科院分区：
文献类型：
--
作者：
D. Fambrough;E. Bayne;J. Gardner;M. Anderson;E. Wakshull;R. Rotundo
脊椎动物身体的大约一半质量是肌肉组织，其中的主要细胞是肌纤维：一种极长的多核细胞，具有与肌腱相互作用的区域专门化表面，用于传播动作电位，并用于接收来自运动神经元的化学信号。运动神经元和肌纤维之间的密切关系一直是神经生物学家特别重视的问题。对神经肌肉接头的研究提供了关于突触通讯的基本信息。此外，肌纤维和运动神经元之间的长期营养相互作用的证据对于神经元连接的可塑性和稳定性的发展非常重要。
About half of the mass of a vertebrate's body is muscle tissue, of which the principal cell is the muscle fiber: an extremely long, multinucleate cell which has a regionally specialized surface for interaction with tendons, for propagation of action potentials, and for reception of chemical signals from motor neurons. The intimate relation between motor neuron and muscle fiber has been of special importance to neurobiologists. Studies of the neuromuscular junction have provided fundamental information about synaptic communication. Furthermore, evidence of long-term trophic interactions between muscle fibers and motor neurons has been important for the development of ideas about the plasticity and stability of neuronal connections.