PTGS2 (COX-2) -765 G>C functional promoter polymorphism and its association with risk and lymph node metastasis in nasopharyngeal carcinoma
PTGS2 (COX-2) -765 G>C functional promoter polymorphism and its association with risk and lymph node metastasis in nasopharyngeal carcinoma
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DOI：
10.1007/s11033-007-9166-3
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发表时间：
2009-01-01
影响因子：
2.8
通讯作者：
Chouchane, Lotfi
中科院分区：
文献类型：
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作者：
Ben Nasr, Hela;Chahed, Karim;Chouchane, Lotfi
环氧合酶-2(COX-2)是花生四烯酸转化为前列腺素的关键酶，在包括鼻咽癌(NPC)在内的多种恶性肿瘤的发生发展中起着重要作用。在目前的报告中，我们设计了一项病例对照研究，以评估功能性-765G>；C基因变异在鼻咽癌中的易感性和预后意义。采用聚合酶链式反应和限制性内切酶片段长度多态性分析方法，对180例鼻咽癌患者和169例健康对照人群进行了基因多态性分析。COX-2-765C等位基因携带者患鼻咽癌的风险较高(OR=1.76；P=0.01)。在调整了年龄和性别后，这种相关性仍然显著(OR=1.89；P=0.008)。在预后指标方面，-765C等位基因携带者与淋巴结转移有关(OR=2.28；P=0.01)，与肿瘤分期有关(OR=2.73；P=0.03)。这是关于鼻咽癌中COX-2基因SNPs研究的第一次报道，我们的数据表明这种基因变异可能在鼻咽癌中起到中介作用
Cyclooxygenase-2 (Cox-2) is a key enzyme in the conversion of arachidonic acid to prostaglandins that has been shown to have a particular importance in the progression of several malignancies including nasopharyngeal carcinoma (NPC). In the current report, we designed a case-controlled study to evaluate the susceptibility and prognostic implications of the functional -765 G > C genetic variation in NPC. A PCR and restriction fragment length polymorphism analysis was used to determine the polymorphism in a Tunisian population of patients with NPC (n = 180) and in healthy control subjects (n = 169). A higher risk for NPC was observed for carriers of COX-2 -765 C allele (OR = 1.76; P = 0.01). This association remains significant after adjustments for age and sex (OR = 1.89; P = 0.008). Regarding prognostic indicators, a significant association was found between -765 C allele carriers and the presence of lymph node metastasis (OR = 2.28; P = 0.01), as well as, with tumor stage (OR = 2.73; P = 0.03). This is the first report on the studies of COX-2 SNPs in NPC and our data suggest that this genetic variant may play a role in mediating