An efficient approach to 2,5-anhydro-glucitol-based 1′-homo-N-nucleoside mimetics
An efficient approach to 2,5-anhydro-glucitol-based 1′-homo-N-nucleoside mimetics
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DOI：
10.1016/j.tetlet.2011.03.090
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发表时间：
2011-05-25
影响因子：
1.8
通讯作者：
von Itzstein, Mark
中科院分区：
文献类型：
--
作者：
Bhatt, Beenu;Thomson, Robin J.;von Itzstein, Mark
本文描述了一系列用4-取代的1，2，3-三唑取代天然核碱基的1 '-高-N-核苷模拟物的有效合成。本文还讨论了6-O-单硫酸化1 '-高-N-核苷模拟物的合成。(C)2011爱思唯尔有限公司保留所有权利。
This Letter describes an efficient synthesis of a range of 1'-homo-N-nucleoside mimetics with a series of 4-substituted 1,2,3-triazoles replacing the natural nucleobase. The synthesis of 6-O-monosulfated 1'-homo-N-nucleoside mimetic derivatives is also discussed. (C) 2011 Elsevier Ltd. All rights reserved.