Epigenetic gene silencing by Runx proteins
Epigenetic gene silencing by Runx proteins
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DOI：
10.1038/sj.onc.1207671
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发表时间：
2004-05-24
期刊：
影响因子：
8
通讯作者：
Littman, DR
中科院分区：
文献类型：
--
作者：
Taniuchi, I;Littman, DR
RUNX家族蛋白具有以上下文相关的方式激活或抑制基因表达的潜力。转录抑制可以通过几种机制发生。一系列广泛的基因座失活，通常被称为基因沉默，被认为是通过染色质莫迪实现的。阳离子。最近发现，RUNX家族蛋白通过在发育的不同阶段与一个CD4沉默因子结合，在转录抑制或不可逆的表观遗传沉默中发挥重要作用。这些发现将RUNX功能与表观基因调控联系起来，并为RUNX抑制靶基因表达的机制提供了新的线索。
Runx family proteins have the potential for either activating or suppressing gene expression in a context-dependent manner. There are several mechanisms by which transcriptional repression can occur. A wide range of locus inactivation, that is often called gene silencing, is thought to be achieved by chromatin modi. cations. Recently, Runx family proteins were found to have an essential role in either temporal transcriptional repression or irreversible epigenetic silencing at the CD4 locus through binding to a CD4 silencer at different stages of development. These findings link Runx function to epigenetic gene regulation, and shed new light on the mechanisms by which Runx represses target gene expression.