A five year follow-up study of dementia in persons with Down's syndrome: early symptoms and patterns of deterioration
A five year follow-up study of dementia in persons with Down's syndrome: early symptoms and patterns of deterioration
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DOI：
10.1017/s0790966700003943
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发表时间：
2000-03-01
影响因子：
5.1
通讯作者：
Lawlor, BA
中科院分区：
文献类型：
--
作者：
Cosgrave, MP;Tyrrell, J;Lawlor, BA
目的：调查女性唐氏综合征患者在5年随访期间的痴呆发展情况；研究人群中痴呆的发病年龄和病程；方法：对50名女性受试者进行为期5年的痴呆患病率、痴呆早期临床特征、痴呆诊断和终末期痴呆评分模式的随访研究。结果：在5年的研究期间，被诊断为痴呆的受试者人数从7人（8.75%）增加到35人（43.75%）。与年龄相关的患病率数据显示，随着年龄的增长，痴呆症更为常见。最早可识别的痴呆症症状是记忆丧失、空间定向障碍和独立性丧失，尤其是在个人卫生方面。研究中使用的评定量表证实了这些发现。结论：痴呆症最早可识别的临床特征包括记忆丧失和依赖性增加。本研究结果将有助于早期诊断退行性痴呆。
Objectives: To investigate the development of dementia over a five year follow up period in a population of females with Down's syndrome; to examine age at onset and duration of dementia in the population; to document the clinical features of dementia and to highlight scores on functional and cognitive rating scales at diagnosis of dementia and at the onset of complete dependencyMethod: A five year follow-up study of SO female subjects on prevalence of dementia, early clinical features of dementia and patterns of scoring on rating scales at diagnosis and end-stage dementia was completed.Results: Over the five year study period the number of subjects diagnosed with dementia rose from seven (8.75%) to 35 (43.75%). Age related prevalence figures showed that dementia was more common with increasing age. The earliest recognisable symptoms of dementia were memory loss, spatial disorientation and loss of independence especially in the area of personal hygiene. These findings were confirmed by the rating scales used in the study.Conclusions: The earliest recognisable clinical features of dementia include memory loss and increased dependency. The results of this study should facilitate earlier diagnosis of dementia in DS.