The effect of quartz, administered by intratracheal instillation, on the rat lung. I. The cellular response.
The effect of quartz, administered by intratracheal instillation, on the rat lung. I. The cellular response.
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DOI：
10.1016/0013-9351(80)90113-9
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发表时间：
1980-06
影响因子：
8.3
通讯作者：
A. Morgan;S. R. Moores;A. Holmes;J. Evans;N. Evans;A. Black
中科院分区：
文献类型：
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作者：
A. Morgan;S. R. Moores;A. Holmes;J. Evans;N. Evans;A. Black
使用支气管肺灌洗研究了肺对气管内滴注石英的反应。对肺泡巨噬细胞和其他游离细胞的恢复的影响进行了描述。研究的其他指标包括肺湿重、巨噬细胞的大小分布和肺中游离巨噬细胞的总数，通过放射性示踪技术估计。在第一系列实验中，在给药后4小时至3个月的不同时间测量对5 mg石英的反应。在第二，在24小时和7天的石英量范围从0.2到10毫克的影响进行了研究。灌洗液中乳酸脱氢酶的测定将在别处报告。
The response of the lung to quartz, administered by intratracheal instillation, was investigated using bronchopulmonary lavage. The effect on the recovery of alveolar macrophages and other free cells is described. Other indices investigated included the wet weight of lung, the size distribution of the macrophages, and the total number of free macrophages in the lung, estimated by means of a radioactive tracer technique. In the first series of experiments the response to 5 mg of quartz was measured at various times from 4 hr to 3 months after administration. In the second, the effect of amounts of quartz ranging from 0.2 to 10 mg was investigated at 24 hr and 7 days. Measurements of lactate dehydrogenase in lavage fluid will be reported elsewhere.