Distant liaisons:: long-range enhancer-promoter interactions in Drosophila
Distant liaisons:: long-range enhancer-promoter interactions in Drosophila
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DOI：
10.1016/s0959-437x(99)00002-7
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发表时间：
1999-10-01
影响因子：
4
通讯作者：
Dorsett, D
中科院分区：
文献类型：
--
作者：
Dorsett, D
许多发育调节基因的转录激活是由与位于启动子数千碱基处的增强子序列结合的蛋白质介导的。现有的激活蛋白功能模型不能充分解释长距离激活。最近的实验在果蝇绝缘体上，阻止增强子-启动子相互作用，染色体间激活，和突变体缺乏远程激活是一致的模型，其中促进因子之间的功能增强子和启动子使他们进入物理接近对方。
Transcriptional activation of many developmentally regulated genes is mediated by proteins binding to enhancer sequences located several kilobases from the promoter. Existing models for how activator proteins function do not adequately explain long-range activation. Recent experiments in Drosophila on insulators that block enhancer-promoter interactions, interchromosomal activation, and mutants deficient in long-range activation are consistent with models in which facilitator factors that function between enhancers and promoters bring them into physical proximity of each other.