Brain tumors and hormonal factors: review of the epidemiological literature
Brain tumors and hormonal factors: review of the epidemiological literature
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DOI：
10.1007/s10552-011-9742-7
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发表时间：
2011-05-01
影响因子：
2.3
通讯作者：
Baldi, Isabelle
中科院分区：
文献类型：
--
作者：
Cowppli-Bony, Anne;Bouvier, Ghislaine;Baldi, Isabelle
背景：中枢神经系统原发性肿瘤（主要是胶质瘤和脑膜瘤）的病因至今仍不清楚。性激素的作用已被建议，根据临床，实验，生物学和流行病学的数据。目的回顾性激素因素与胶质瘤和脑膜瘤的发生之间的关系的流行病学研究，以确定新的研究进展。方法选择到2010年9月发表的文章，考虑外源性和内源性暴露和特定的脑肿瘤。标准化的信息收集了20篇文章：15个关于胶质瘤和13 meningoma.Results胶质瘤的风险增加，观察到月经初潮和绝经后，而减少胶质瘤的风险，观察激素替代治疗（HRT）和口服避孕药的使用，尽管使用时间没有影响的风险。绝经后和HRT使用后脑膜瘤风险增加。没有明确的关联被发现与怀孕和哺乳。结论结果是全球一致的生物学假设，假设女性性激素是保护性的胶质瘤，并可能增加脑膜瘤的风险。然而，应进行新的流行病学研究，以确认这些协会，并完善激素因素在脑病因中的作用。
Background To date, the etiology of primary tumors of the central nervous system (mainly gliomas and meningiomas) is poorly understood. The role of sex hormones has been suggested, based on clinical, experimental, biological, and epidemiological data.Objective To review the epidemiological studies on the relation between hormonal factors and the occurrence of glioma and meningioma, in order to identify new research developments.Methods Articles published until September 2010 were selected by considering exogenous and endogenous exposures and specific brain tumors. Standardized information was collected from 20 articles: 15 concerning gliomas and 13 meningiomas.Results An increased glioma risk was observed with later menarche and menopause, while a reduced glioma risk was observed with hormone replacement therapy (HRT) and oral contraceptive use, despite duration of use had no effect on risk. Meningioma risk increased after menopause and with HRT use. No clear association was found with pregnancy and breastfeeding.Conclusion Results are globally concordant with the biologic hypothesis assuming that female sex hormones are protective against glioma and may increase the risk of meningioma. However, new epidemiological studies should be conducted in order to confirm these associations and to refine the role of hormonal factors in brain etiology.