A MODEL TO PREDICT THE HISTOPATHOLOGY OF HUMAN STROKE USING DIFFUSION AND T-2-WEIGHTED MAGNETIC-RESONANCE-IMAGING
A MODEL TO PREDICT THE HISTOPATHOLOGY OF HUMAN STROKE USING DIFFUSION AND T-2-WEIGHTED MAGNETIC-RESONANCE-IMAGING
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DOI：
10.1161/01.str.26.11.1983
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发表时间：
1995-11-01
期刊：
影响因子：
8.3
通讯作者：
LEVINE, SR
中科院分区：
文献类型：
--
作者：
WELCH, KMA;WINDHAM, J;LEVINE, SR
背景和目的我们试图确定在短采集时间内具有高概率预测的MRI测量，在缺血发作后的早期时间点，方法我们基于水的表观扩散系数（ADC（W））和T-的实验导出的关系开发了MR组织签名模型。2例为缺血性脑组织病理学改变。在8例脑卒中患者中，我们使用弥散加权回波平面成像（DW-EPI）测量ADC（W）和T-2强度。定义组织特征区域，并生成卒中发作后亚急性时间点缺血灶的主题图。结果在人类卒中灶中识别出五个MR特征：两个可以预测细胞恢复或进展到坏死，一个可以标记向细胞坏死的转变，结论使用ADC（W）和T-2现在可以测试其预测人类缺血性脑区域中可逆性和不可逆性细胞损伤的潜力。
Background and Purpose We sought to identify MRI measures that have high probability in a short acquisition time to predict, at early time points after onset of ischemia, the eventual development of cerebral infarction in clinical patients who suffer occlusion of a cerebral artery.Methods We developed an MR tissue signature model based on experimentally derived relationships of the apparent diffusion coefficient of water (ADC(W)) and T-2 to ischemic brain tissue histopathology. In eight stroke patients we measured ADC(W) and T-2 intensity using diffusion-weighted echo-planar imaging (DW-EPI). Tissue signature regions were defined, and theme maps of the ischemic focus at subacute time paints after stroke onset were generated.Results Five MR signatures were identified in human stroke foci: two that may predict either cell recovery or progression to necrosis, one that may mark the transition to cell necrosis, and two that may be markers of established cell necrosis.Conclusions An MR tissue signature model of ischemic histopathology using ADC(W) and T-2 can now be tested for its potential to predict reversible and identify irreversible cellular damage in human ischemic brain regions.