Effect of MDMA (ecstasy) on activity and cocaine conditioned place preference in adult and adolescent rats
Effect of MDMA (ecstasy) on activity and cocaine conditioned place preference in adult and adolescent rats
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DOI：
10.1016/j.ntt.2006.09.002
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发表时间：
2007-01-01
影响因子：
2.9
通讯作者：
Izenwasser, Sari
中科院分区：
文献类型：
--
作者：
Aberg, Maria;Wade, Dean;Izenwasser, Sari
MDMA（摇头丸）是青少年常用的药物，许多MDMA使用者还使用其他非法药物。目前尚不清楚青春期的MDMA是否会以不同于成年人的方式改变随后对可卡因的反应。本研究考察了MDMA对青少年和成年大鼠可卡因条件性奖赏的影响。在这些实验开始时，青春期大鼠在出生后第33天（PND），成年大鼠在PND 60。每只大鼠用MDMA（2或5 mg/kg/天或溶剂）处理7天，并测量自发活动。5天后，开始可卡因条件性位置偏爱（CPP）。大鼠训练3天，上午用生理盐水，下午用10 mg/kg可卡因，每次30 min，第4天进行测试。MDMA刺激了两个年龄组的活动，但对成年大鼠的影响更大。成年大鼠和两组大鼠均对较低剂量MDMA的运动刺激效应产生了敏化作用，而对较高剂量的MDMA则产生了敏化作用。在溶媒给药的青春期大鼠中，考地平未产生CPP，但在用MDMA给药后观察到显著的CPP。与此相反，可卡因诱导的CPP减少MDMA成年大鼠后。这些影响在2周后重新测试时仍然明显。因此，在目前的条件下，MDMA增加可卡因条件奖励在青少年和减少它在成年大鼠。这些研究结果表明，在这一关键的发育时期接触MDMA可能比成年期具有更大的风险，并且在使用MDMA后，交配青少年可能特别容易受到兴奋剂滥用的风险。(c)2006年爱思唯尔公司All rights reserved.
MDMA (ecstasy) is a drug commonly used in adolescence, and many users of MDMA also use other illicit drugs. It is not known whether MDMA during adolescence alters subsequent responses to cocaine differently than in adults. This study examined the effects of MDMA in adolescent and adult rats on cocaine conditioned reward. At the start of these experiments, adolescent rats were at postnatal day (PND) 33 and adult rats at PND 60. Each rat was treated for 7 days with MDMA (2 or 5 mg/kg/day or vehicle) and locomotor activity was measured. Five days later cocaine conditioned place preference (CPP) was begun. Rats were trained for 3 days, in the morning with saline and in the afternoon with 10 mg/kg cocaine in 30 min sessions, and tested on the fourth day. MDMA stimulated activity in both age groups, but with a greater effect in the adult rats. Sensitization to the locomotor-stimulant effects of the lower dose of MDMA occurred in adult rats and in both groups to the higher dose. Cocaine did not produce a CPP in vehicle-treated adolescent rats, but a significant CPP was observed subsequent to treatment with MDMA. In contrast, cocaine-induced CPP was diminished after MDMA in adult rats. These effects were still evident 2 weeks later upon retest. Thus, under the present conditions, MDMA increased cocaine conditioned reward in adolescent and decreased it in adult rats. These findings suggest that exposure to MDMA during this critical developmental period may carry a greater risk than during adulthood and that mate adolescents may be particularly vulnerable to the risk of stimulant abuse after use of MDMA. (c) 2006 Elsevier Inc. All rights reserved.