Cu-Catalyzed Aerobic Oxidation of Alcohols with a Multi-Functional NMI-TEMPO
Cu-Catalyzed Aerobic Oxidation of Alcohols with a Multi-Functional NMI-TEMPO
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使用多功能 NMI-TEMPO 进行铜催化醇类有氧氧化
DOI：
10.1002/slct.201800398
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发表时间：
2018
期刊：
影响因子：
2.1
通讯作者：
Gao Shuang
中科院分区：
文献类型：
--
作者：
Wang Lianyue;Bie Zhixing;Shang Sensen;Li Guosong;Niu Jingyang;Gao Shuang
一种新的、易获得的N-甲基咪唑衍生的TEMPO作为多功能分子，与商业上可获得的碘化铜和4，4‘-二叔丁基-2，2’-联吡啶相结合，提供了一种催化剂体系，在常温气球下对多种醇类的氧化表现出高效的活性。以较好的产率得到了相应的醛和酮。这一过程很容易扩大。该催化体系对仲醇具有较高的化学选择性。铜(I)原位生成的活性物种对醇类化合物的氧化起主要作用。
A novel and easily accessibleN‐methylimidazole derived TEMPO as multi‐functional molecule combining with commercially available copper(I) iodide and 4,4′‐Di‐tert‐butyl‐2,2′‐dipyridyl afford a catalyst system that shows efficient activity for the oxidation of a broad scope of alcohols under air balloon at room temperature. The corresponding aldehydes and ketones were obtained in good to excellent yields. The procedure is readily amenable to scale up. The present catalytic system shows a high chemoselective oxidation of primary alcohols over secondary alcohols. Cu(II) active species generated in situ from Cu(I) is responsible for the oxidation of alcohols.