High resolution multimodal clinical ophthalmic imaging system.
High resolution multimodal clinical ophthalmic imaging system.
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DOI：
10.1364/oe.18.011607
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发表时间：
2010-05-24
期刊：
影响因子：
3.8
通讯作者：
Hammer DX
中科院分区：
文献类型：
--
作者：
Mujat M;Ferguson RD;Patel AH;Iftimia N;Lue N;Hammer DX
我们开发了一种多模式自适应光学(AO)视网膜成像仪，它首次在一个紧凑的临床原型平台上结合了高性能的光学校正激光眼底镜(SLO)和扫描源傅立叶域光学相干断层成像(SSOCT)成像模式。这类系统对视觉研究变得越来越重要，并有望证明它们在诊断视网膜疾病方面的临床价值，包括青光眼、糖尿病视网膜病变(DR)、老年性黄斑变性(AMD)和视网膜色素变性。SSOCT通道在1微米波长下运行，以增加对脉络膜毛细血管和脉络膜的穿透和可视化，这两个部位是DR和湿性AMD的主要疾病活动部位。这种光学系统是为临床人群设计的；双变形镜(DM)配置允许在大范围的屈光和眼部媒体质量上同时进行低阶和高阶像差校正。该系统还包括宽视野(33°)。用于初始筛查、目标识别和全球定位的线扫描检眼镜(LSO)，用于在存在眼部侧向运动的情况下稳定SLO、OCT和LSO成像场的集成视网膜跟踪器(RT)，以及用于呈现视觉提示的高分辨率LCD固定靶标。该系统在没有视网膜疾病的受试者身上进行了测试，以进行性能优化和验证。我们能够分辨和量化整个黄斑的视锥感光细胞，使其在中心凹约0.5度(~100-150微米)范围内，成像并描绘出10个视网膜层，并穿透以分辨脉络膜深处的特征。这里展示的原型是新一类功能强大的灵活成像平台的第一个，该平台将为临床医生和研究人员提供高分辨率、高性能的自适应光学成像，以帮助指导治疗、开发新药和改善患者结果。
We developed a multimodal adaptive optics (AO) retinal imager which is the first to combine high performance AO-corrected scanning laser ophthalmoscopy (SLO) and swept source Fourier domain optical coherence tomography (SSOCT) imaging modes in a single compact clinical prototype platform. Such systems are becoming ever more essential to vision research and are expected to prove their clinical value for diagnosis of retinal diseases, including glaucoma, diabetic retinopathy (DR), age-related macular degeneration (AMD), and retinitis pigmentosa. The SSOCT channel operates at a wavelength of 1 µm for increased penetration and visualization of the choriocapillaris and choroid, sites of major disease activity for DR and wet AMD. This AO system is designed for use in clinical populations; a dual deformable mirror (DM) configuration allows simultaneous low- and high-order aberration correction over a large range of refractions and ocular media quality. The system also includes a wide field (33 deg.) line scanning ophthalmoscope (LSO) for initial screening, target identification, and global orientation, an integrated retinal tracker (RT) to stabilize the SLO, OCT, and LSO imaging fields in the presence of lateral eye motion, and a high-resolution LCD-based fixation target for presentation of visual cues. The system was tested in human subjects without retinal disease for performance optimization and validation. We were able to resolve and quantify cone photoreceptors across the macula to within ~0.5 deg (~100-150 µm) of the fovea, image and delineate ten retinal layers, and penetrate to resolve features deep into the choroid. The prototype presented here is the first of a new class of powerful flexible imaging platforms that will provide clinicians and researchers with high-resolution, high performance adaptive optics imaging to help guide therapies, develop new drugs, and improve patient outcomes.