Imaging of macular diseases with optical coherence tomography.
Imaging of macular diseases with optical coherence tomography.
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DOI：
10.1016/s0161-6420(95)31032-9
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发表时间：
1995-02
期刊：
影响因子：
13.7
通讯作者：
C. Puliafito;M. Hee;Charles P. Lin;E. Reichel;J. Schuman;J. Duker;J. Izatt;E. Swanson;J. Fujimoto-J.-Fu
中科院分区：
文献类型：
--
作者：
C. Puliafito;M. Hee;Charles P. Lin;E. Reichel;J. Schuman;J. Duker;J. Izatt;E. Swanson;J. Fujimoto-J.-Fu
背景/目的：评估一种新的诊断技术，称为光学相干断层扫描成像黄斑疾病的潜力。光学相干断层扫描是一种新型的非侵入性、非接触式成像方式，可产生高深度分辨率（10 μm）的眼组织断层图像。这是类似于超声波，除了光学，而不是声反射率measurement.Methods：光学相干断层扫描图像的黄斑获得在51只眼睛的44例选定的黄斑疾病。成像的方式与裂隙灯间接生物显微镜兼容，使高分辨率的光学断层扫描可以与正常的眼科检查同时完成。使用低相干干涉测量法确定从视网膜中的不同层反向散射的光的飞行时间延迟。在2.5秒内获得视网膜剖面光学反射率与组织距离的横截面断层扫描图，纵向分辨率为10 μm。结果：在12只患有以下病变的眼睛中，证实了眼底检查和荧光素血管造影与光学相干断层扫描图的相关性：全层和部分层黄斑裂孔、视网膜前膜、黄斑水肿、视网膜内渗出物、特发性中心性浆液性脉络膜视网膜病变，结论：光学相干断层扫描是一种有效的检测黄斑水肿、黄斑裂孔、视网膜神经上皮和色素上皮脱离等黄斑病变的方法。
Background/Purpose:To assess the potential of a new diagnostic technique called optical coherence tomography for imaging macular disease. Optical coherence tomography is a novel noninvasive, noncontact imaging modality which produces high depth resolution (10 μm cross-sectional tomographs of ocular tissue. It is analogous to ultrasound, except that optical rather than acoustic reflectivity is measured.Methods:Optical coherence tomography images of the macula were obtained in 51 eyes of 44 patients with selected macular diseases. Imaging is performed in a manner compatible with slit-lamp indirect biomicroscopy so that high-resolution optical tomography may be accomplished simultaneously with normal ophthalmic examination. The time-of-flight delay of light backscattered from different layers in the retina is determined using low-coherence interferometry. Cross-sectional tomographs of the retina profiling optical reflectivity versus distance into the tissue are obtained in 2.5 seconds and with a longitudinal resolution of 10 μm.Results:Correlation of fundus examination and fluorescein angiography with optical coherence tomography tomographs was demonstrated in 12 eyes with the following pathologies: full- and partial-thickness macular hole, epiretinal membrane, macular edema, intraretinal exudate, idiopathic central serous chorioretinopathy, and detachments of the pigment epithelium and neurosensory retina.Conclusion:Optical coherence tomography is potentially a powerful tool for detecting and monitoring a variety of macular diseases, including macular edema, macular holes, and detachments of the neurosensory retina and pigment epithelium.