Macrophyllionium and Macrophyllines A and B, Oxindole Alkaloids from Uncaria macrophylla
Macrophyllionium and Macrophyllines A and B, Oxindole Alkaloids from Uncaria macrophylla
复制标题
Macrophylliium 和 Macrophyllines A 和 B，来自钩藤的羟吲哚生物碱
DOI：
10.1021/np1004938
复制
发表时间：
2011-01-01
影响因子：
5.1
通讯作者：
Zhao, Qin-Shi
中科院分区：
文献类型：
--
作者：
Wang, Kou;Zhou, Xiao-Yu;Zhao, Qin-Shi
从大叶钩藤（Uncaria macrophyllla）的地上部分分离得到一种新的氧化吲哚生物碱内盐macrophyllionium（1），一对新的四环氧化吲哚生物碱macrophyllines A（2）和B（3），以及六种已知生物碱。柯楠替啶（8）对HL-60和SW 480细胞显示中等细胞毒性，IC 50值分别为13.96和23.28 μ M。二氢柯楠酰巯基乙胺（9）对苯肾上腺素诱导的大鼠胸主动脉环收缩表现出显著的血管舒张活性（IC 50 = 6.73 μ g/mL）。此外，化合物2、6和9对KO诱导的收缩表现出弱的抑制作用。
An unusual oxindole alkaloid inner salt, macrophyllionium (1), and a pair of new tetracyclic oxindole alkaloids, macrophyllines A (2) and B (3), together with six known alkaloids, were isolated from the aerial parts of Uncaria macrophylla. Corynantheidine (8) exhibited moderate cytotoxicity against HL-60 and SW480 cells with IC50 values of 13.96 and 23.28 mu M, respectively. Dihydrocorynantheine (9) exhibited significant vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta rings (IC50 = 6.73 mu g/mL). In addition, compounds 2, 6, and 9 showed weak inhibitory action on KO-induced contraction.