Protective effect of practice on cognition during aging: Implications for predictive characteristics of performance and efficacy of practice
Protective effect of practice on cognition during aging: Implications for predictive characteristics of performance and efficacy of practice
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DOI：
10.1006/nlme.2002.4064
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发表时间：
2002-09-01
影响因子：
2.7
通讯作者：
Savonenko, AV
中科院分区：
文献类型：
--
作者：
Markowska, AL;Savonenko, AV
在本研究中，以前的经验对空间记忆的影响，这需要长时间间隔或在一个单一的会话中保留的信息，纵向测试在水迷宫中的雄性F-344大鼠，从6至24个月的年龄。发现这些任务的表现与年龄有关（Markowska，1999年）。其他行为任务在直巷和一个可见的平台在水迷宫控制的非认知成分的性能。对于所有的任务，性能之间显着相关的12个月大和18个月大的大鼠，这表明认知性能在早期，但不是先进的，老化阶段可以预测的性能在较年轻的年龄，如果第一次接触的任务的新奇被淘汰。经验的保护作用是更强大的参考记忆任务相比，工作记忆任务，并修改了年龄时，培训开始。与平台试验中的表现相比，探针试验期间的行为对老化的影响更敏感，对实践的有益效果更有抵抗力。有经验的大鼠的游泳速度随着年龄的增长而逐渐下降，只有在认知任务中进行测试，但在直巷。这表明认知任务中的游泳速度并不完全反映游泳能力，但也可能受到任务的认知需求的影响。经验对认知功能的保护作用可被饮食限制所修正。(C)2002 Elsevier Science（美国）。
In the present study, the effect of previous experience on spatial memory, which required the retention of information either over long intervals or within a single session, was longitudinally tested in the water maze in male F-344 rats that were from 6 to 24 months of age. Performance in these tasks was found to be age-dependent (Markowska, 1999). Other behavioral tasks in the Straight alley and with a visible platform in the water maze controlled the noncognitive components of performance. For all tasks, performance was significantly correlated between 12-month-old and 18-month-old rats, indicating that cognitive performance at the early, but not advanced, stage of aging could be predicted from performance at a younger age if the novelty of the first exposure to the task was eliminated. The protective effect of experience was more robust in the reference memory task as compared to the working memory task and was modified by age when training was initiated. Behavior during the probe trials was more sensitive to the effect of aging and more resistant to the beneficial effect of practice as compared to the performance in the platform trials. The speed of swimming of experienced rats progressively decreased with age only when tested in the cognitive tasks but not in the straight alley. This indicates that speed of swimming during cognitive tasks does not exclusively reflect the ability to swim, but might be also affected by the cognitive demands of the task. Protective effect of experience on cognition was Dot modified by restriction in diet. (C) 2002 Elsevier Science (USA).