In vivo diffusion tensor imaging of the rat spinal cord at 9.4T.
In vivo diffusion tensor imaging of the rat spinal cord at 9.4T.
复制标题
9.4T 大鼠脊髓体内扩散张量成像。
DOI：
10.1002/jmri.21249
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Schmit,BrianD
中科院分区：
文献类型：
--
作者：
Ellingson,BenjaminM;Kurpad,ShekarN;Li,Shi-Jiang;Schmit,BrianD
PurposeTo determine differences in diffusion measurements in white matter (WM) and gray matter (GM) regions of the rat cervical, thoracic, and cauda equina spinal cord using in vivo diffusion tensor imaging (DTI) with a 9.4T MR scanner.Materials and MethodsDTI was performed on seven rats in three slices at the cervical, thoracic, and cauda equina regions of the spinal cord using a 9.4T magnet. Axial diffusion weighted images (DWIs) were collected at ab‐value of 1000 seconds/mm2in six directions. Regions of interest were identified via T2‐weighted images for the lateral, dorsal, and ventral funiculi, along with GM regions.ResultsAnalysis of variance (ANOVA) results indicated significant differences between every WM funiculus compared to GM for longitudinal apparent diffusion coefficient (lADC), transverse apparent diffusion coefficient (tADC), fractional anisotropy (FA), measured longitudinal anisotropy (MA1), and anisotropy index (AI). A significant difference in mean diffusivity (MD) between regions of the spinal cord was not found. Diffusion measurements were significantly different at each spinal level. In general, GM regions were significantly different than WM regions; however, there were few significant differences between individual WM regions.ConclusionIn vivo DTI of the rat spinal cord at 9.4T appears sensitive to the architecture of neural structures in the rat spinal cord and may be a useful tool in studying trauma and pathologies in the spinal cord. J. Magn. Reson. Imaging 2008. © 2008 Wiley‐Liss, Inc.
