Symptom profile of multiple chemical sensitivity in actual life
Symptom profile of multiple chemical sensitivity in actual life
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DOI：
10.1097/01.psy.0000155676.69030.28
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发表时间：
2005-03-01
影响因子：
3.3
通讯作者：
Kuboki, T
中科院分区：
文献类型：
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作者：
Saito, M;Kumano, H;Kuboki, T
目的：本研究旨在确认实际生活中多重化学物质敏感性（MCS）的定义：通过暴露于低水平的多种化学物质，在多个器官中引起多种症状，并通过避免多种化学物质而改善。我们使用生态瞬时评估来监测日常症状，并使用主动采样和被动采样方法来测量环境化学品暴露。方法：18例MCS患者，根据1999年共识标准诊断，12名健康对照参加了这项研究。14名患者和12名对照者接受了为期1周的身体和心理症状以及各种化学物质暴露水平的测量。使用线性混合模型来检验关于MCS患者症状特征的假设。结果：14例MCS患者中有11例检出致病化学物质。另外两名患者没有报告任何超敏反应事件，而被动采样显示，接触化学物质远低于对照组。另一例受试者报告了偶发症状，但由于未检测到可能的化学物质而被排除在以下分析之外。在基于“患者发起的症状提示”的访谈中，17种身体症状中的11种和所有4种情绪分量表都显著加重。另一方面，在基于“随机提示”的访谈中，MCS患者和对照组之间的身体症状或情绪分量表没有差异。“结论：MCS患者在无化学品条件下没有躯体或心理症状，只有暴露于化学品时才可能引起症状。
Objective: This study was conducted to confirm the definition of multiple chemical sensitivity (MCS) in actual life: that multiple symptoms are provoked in multiple organs by exposure to, and ameliorated by avoidance of, multiple chemicals at low levels. We used the Ecological Momentary Assessment to monitor everyday symptoms and the active sampling and passive sampling methods to measure environmental chemical exposure. Methods: Eighteen patients with MCS, diagnosed according to the 1999 consensus criteria, and 12 healthy controls participated in this study. Fourteen patients and 12 controls underwent 1-week measurement of physical and psychologic symptoms and of the levels of exposure to various chemicals. Linear mixed models were used to test the hypotheses regarding the symptom profile of MCS patients. Results: Some causative chemicals were detected in 11 of 14 MCS patients. Two other patients did not report any hypersensitivity episodes, whereas passive sampling showed far less exposure to chemicals than control subjects. Another subject reported episodic symptoms but was excluded from the following analyses because no possible chemical was detected. Eleven of the 17 physical symptoms and all four mood subscales examined were significantly aggravated in the interview based on "patient-initiated symptom prompts." On the other hand, there were no differences in physical symptoms or mood subscales between MCS patients and control subjects in the interview based on "random prompts." Conclusions: MCS patients do not have either somatic or psychologic symptoms under chemical-free conditions, and symptoms may be provoked only when exposed to chemicals.