Contribution of NADPH oxidase to the establishment of hippocampal neuronal polarity in culture
Contribution of NADPH oxidase to the establishment of hippocampal neuronal polarity in culture
复制标题
NADPH 氧化酶对培养物中海马神经元极性建立的贡献
DOI：
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发表时间：
2015
影响因子：
4
通讯作者：
Christian Gonzaíez
中科院分区：
文献类型：
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作者：
Carlos Wilson;M. Tulio;Nún Ez;Christian Gonzaíez
摘要 NADPH 氧化酶 (NOX) 复合物产生的活性氧 (ROS) 分别在神经传递和神经变性中发挥重要的生理和病理作用。然而，ROS 对神经元极性和轴突伸长的分子机制的贡献尚不清楚。在这项工作中，我们发现 NOX 复合体功能的丧失通过涉及肌动蛋白细胞骨架动力学的机制改变了神经元极化并减少了轴突长度。这些结果表明，NOX复合物产生的ROS的生理水平在体外调节海马神经元极性和轴突生长。摘要：NOX 功能参与神经元极性的建立。
ABSTRACT Reactive oxygen species (ROS) produced by the NADPH oxidase (NOX) complex play important physiological and pathological roles in neurotransmission and neurodegeneration, respectively. However, the contribution of ROS to the molecular mechanisms involved in neuronal polarity and axon elongation is not well understood. In this work, we found that loss of NOX complex function altered neuronal polarization and decreased axonal length by a mechanism that involves actin cytoskeleton dynamics. These results indicate that physiological levels of ROS produced by the NOX complex modulate hippocampal neuronal polarity and axonal growth in vitro. Summary: NOX function is involved in the establishment of neuronal polarity.
影响因子：
32.4
作者：
Sakai J;Li J;Subramanian KK;Mondal S;Bajrami B;Hattori H;Jia Y;Dickinson BC;Zhong J;Ye K;Chang CJ;Ho YS;Zhou J;Luo HR
通讯作者：
Luo HR
影响因子：
7.5
作者：
Terman, Jonathan R.;Kashina, Anna
通讯作者：
Kashina, Anna