A porphyrin-basesd fluorescent probe for optical detection of toxic Cd2+ ion in aqueous solution and living cells
A porphyrin-basesd fluorescent probe for optical detection of toxic Cd2+ ion in aqueous solution and living cells
复制标题
一种基于卟啉的荧光探针，用于光学检测水溶液和活细胞中有毒 Cd2 离子
DOI：
10.1016/j.dyepig.2017.05.001
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发表时间：
2017-08-01
影响因子：
4.5
通讯作者：
Shen, Jie
中科院分区：
文献类型：
--
作者：
Huang, Wen-Bin;Gu, Wei;Shen, Jie
报道了一种基于卟啉的水溶液中镉离子(Cd~(2+))的比例荧光检测方法。该探针含有两个2，2‘-联吡啶胺(DPA)基团作为金属络合部分，通过分子内电荷转移(ICT)过程的中断，与Cd~(2+)显示出络合产生的比率荧光效应。该探针具有大的比例尺荧光信号，在生理pH窗口中检测Cd~(2+)时，具有高灵敏度、高选择性和快速响应，检测下限为百万分之几(Ppb)。此外，它具有很低的细胞毒性，可以利用激光扫描共聚焦显微镜观察活细胞内的CD2+。(C)2017爱思唯尔有限公司。保留所有权利。
A porphyrin-based water-soluble fluorescent probe was reported for ratiometric detection of cadmium ion (Cd2+) in aqueous solution. This probe bearing two 2,2'-dipyridylamine (DPA) groups as metal chelating moieties which show chelation-produced ratiometric fluorescence effect with Cd2+ via the interruption of intramolecular charge transfer (ICT) process. Exhibiting a large ratiometric fluorescence signal, the probe shows high sensitivity, high selectivity as well as quick response when detecting Cd2+ in the physiological pH window with a detection limit of part per billion (ppb) level. Moreover, it displays very low cytotoxicity and can be employed to visualize intracellular Cd2+ in living cells by utilizing laser scanning confocal microscopy. (C) 2017 Elsevier Ltd. All rights reserved.