Global Pediatric Research Investigator: Modupe Coker.
Global Pediatric Research Investigator: Modupe Coker.
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DOI：
10.1038/s41390-020-01241-4
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发表时间：
2021-04
影响因子：
3.6
通讯作者：
Coker M
中科院分区：
文献类型：
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作者：
Coker M
从童年起，我就对数据科学的世界着迷，特别是了解儿科人群中复杂的疾病模式，希望为预防和持续治疗提供有效的公共卫生措施。我对研究儿童和青少年的兴趣始于学习牙科，在那里我参与研究了幼儿感染人类免疫缺陷病毒（HIV）的口腔表现的流行病学。这种兴趣已经发展了多年，是我对传染病流行病学，儿科和新生儿微生物学和免疫学感兴趣的基础。我特别感兴趣的是早期生活暴露（如免疫状态，营养和抗生素）如何驱动肠道，口腔和牙齿微生物组的发展。我目前资助的研究重点是研究围产期艾滋病毒感染或暴露对尼日利亚儿童早期龋齿风险和口腔微生物组发育的影响（co-PI-Dr理查兹）。我还担任研究员与新罕布什尔州出生队列根据美国国立卫生研究院资助的环境影响儿童健康结果（ECHO）计划（PI-Karagas），和囊性纤维化微生物组队列（PI-Madan），我们专注于了解早期生活暴露对发展肠道和口腔微生物组的影响。多年来，有几个人在鼓励和支持我方面发挥了关键作用。布拉特纳博士、查鲁拉特博士、索尔金博士、卡拉加斯博士、马丹博士和霍恩博士是其中的关键人物，他们中的许多人今天仍然是我的导师。关于最近发表的儿科研究叙述性综述，重点关注生活在撒哈拉以南非洲的儿童中与COVID-19相关的涟漪效应，Nadia Sam-Agudu博士和Morenike Ukpong教授表现出了模范的领导力和卓越，我很感谢有机会与他们和该领域的其他著名专家一起撰写这篇综述。
Since my childhood, I have been fascinated with the world of data sciences particularly understanding complex patterns of disease in pediatric populations with the hope of informing effective public health measures for prevention and sustained treatment. My interest in studying children and adolescents began while studying dentistry, where I was involved in studying the epidemiology of oral manifestations of human immunodeficiency virus (HIV) infection in young children. This interest has evolved over the years and was the foundation of my interest in infectious disease epidemiology, pediatric and neonatal microbiology, and immunology. I am particularly interested in how early-life exposures (like immune status, nutrition, and antibiotics) drive development of the gut, oral, and dental microbiomes. My currently funded research is focused on studying the impact of perinatal HIV infection or exposure on the risk of early childhood caries and the developing oral microbiomes in Nigerian children (co-PI-Dr Richards). I also serve as an investigator with New Hampshire Birth Cohort under the NIH-funded Environmental influences on Child Health Outcomes (ECHO) program (PI-Karagas), and the Cystic Fibrosis Microbiome Cohort (PI-Madan) where we are focused on understanding the impact of early-life exposures on the developing gut and oral microbiome. Several people have played key roles in encouraging and supporting me over the years. Drs. Blattner, Charurat, Sorkin, Karagas, Madan, and Hoen are among the key players, many of whom still mentor me today. In reference to the recently published Pediatric Research narrative review focused on the COVID-19-related ripple effects in children living in sub-Saharan Africa, Dr. Nadia Sam-Agudu and Prof. Morenike Ukpong have displayed exemplary leadership and excellence, and I am grateful for the opportunity to author this review with them and other notable experts in the field.