EFFECT OF FUNDIC DISTENSION ON GASTRIC-ACID SECRETION IN MAN
EFFECT OF FUNDIC DISTENSION ON GASTRIC-ACID SECRETION IN MAN
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作者：
GROTZINGER, U;BERGEGARDH, S;OLBE, L
本文观察了26例十二指肠溃疡病人和6例健康人胃底和胃体扩张对胃酸分泌的影响。通过将橡胶气囊充气至150、300和600 ml体积而产生的分级扩张导致酸输出的显著连续增加。分泌反应比刺激持续至少1 h。在这两组受试者中，胃底扩张可获得的最高酸输出量相当于静脉输注五肽胃泌素诱发的最大分泌反应的50%以上。在胃底扩张期间和五肽胃泌素刺激后观察到的峰值分泌率之间存在显著相关性。人的泌酸腺区域的扩张是胃酸分泌的有力刺激;十二指肠溃疡患者对这种刺激并不比健康受试者更敏感。
The effect of distension of the fundus and body of the stomach on gastric acid secretion was studied in 26 patients with duodenal ulcer and 6 healthy subjects. Graded distension produced by inflating a rubber balloon to volumes of 150, 300 and 600 ml resulted in significant sequential increments of acid output. The secretory response outlasted stimulation by at least 1 h. In both groups of subjects, the highest acid output obtainable with fundic distension amounted to just above 50% of the maximum secretory response evoked by i.v. infusion of pentagastrin. A significant correlation was found between the peak secretory rates observed during fundic distension and after pentagastrin stimulation. Distension of the oxyntic gland area in man is a potent stimulus for gastric secretion of acid; patients with duodenal ulcer are no more sensitive to this stimulus than healthy subjects.